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An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas

OBJECTIVE: Accurate and noninvasive pathologic grading of glioma patients before surgery was crucial to guiding clinicians to select appropriate treatment and improve patient prognosis. This study was performed to investigate the potential diagnostic value of diffusion kurtosis imaging (DKI) to dist...

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Autores principales: Huang, Ruiyu, Chen, Yanni, Li, Wenfei, Zhang, Xvfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221635/
https://www.ncbi.nlm.nih.gov/pubmed/30383687
http://dx.doi.org/10.1097/MD.0000000000013068
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author Huang, Ruiyu
Chen, Yanni
Li, Wenfei
Zhang, Xvfeng
author_facet Huang, Ruiyu
Chen, Yanni
Li, Wenfei
Zhang, Xvfeng
author_sort Huang, Ruiyu
collection PubMed
description OBJECTIVE: Accurate and noninvasive pathologic grading of glioma patients before surgery was crucial to guiding clinicians to select appropriate treatment and improve patient prognosis. This study was performed to investigate the potential diagnostic value of diffusion kurtosis imaging (DKI) to distinguish high-grade gliomas (HGGs) from low-grade gliomas (LGGs) based on an evidence-based approach. METHODS: Relevant articles that used DKI to distinguish HGG from LGG in Embase, PubMed, China Knowledge Resource Integrated database (CNKI), Web of Knowledge, and Cochrane Libraries databases were electronically searched to April 31, 2018 by 2 reviewers. All analysis was performed by using Meta-disc1.4 and Stata. Influence factors on the diagnostic accuracy were evaluated using meta-regression analysis. RESULTS: Five eligible studies were included in this meta-analysis. The pooled sensitivity (SEN) and specificity (SPE) was 91% (confidence interval [CI]: 0.78–0.96; P = .02) and 91% (CI: 0.80–0.97; P = .01). The pooled data showed that diagnostic odds ratio (DOR) of DKI was 79.75 (CI: 31.57–201.45). The area under the curve (AUC) of summary receiver operating characteristic curve was 0.96. There is no evidence that our research has a threshold effect (Spearman correlation coefficient: 0.300, P = .624) and publication bias. Meta regression analysis identified that country, language, field strength, and parameter of magnetic resonance imaging had no significant effect on diagnostic performance. CONCLUSION: The present meta-analysis shows that the mean kurtosis values derived from DKI may be useful in characterization of gliomas with high sensitivity and specificity. Taken into consideration the small sample of this study, we need to be cautious when interpreting the results of this study.
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spelling pubmed-62216352018-12-04 An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas Huang, Ruiyu Chen, Yanni Li, Wenfei Zhang, Xvfeng Medicine (Baltimore) Research Article OBJECTIVE: Accurate and noninvasive pathologic grading of glioma patients before surgery was crucial to guiding clinicians to select appropriate treatment and improve patient prognosis. This study was performed to investigate the potential diagnostic value of diffusion kurtosis imaging (DKI) to distinguish high-grade gliomas (HGGs) from low-grade gliomas (LGGs) based on an evidence-based approach. METHODS: Relevant articles that used DKI to distinguish HGG from LGG in Embase, PubMed, China Knowledge Resource Integrated database (CNKI), Web of Knowledge, and Cochrane Libraries databases were electronically searched to April 31, 2018 by 2 reviewers. All analysis was performed by using Meta-disc1.4 and Stata. Influence factors on the diagnostic accuracy were evaluated using meta-regression analysis. RESULTS: Five eligible studies were included in this meta-analysis. The pooled sensitivity (SEN) and specificity (SPE) was 91% (confidence interval [CI]: 0.78–0.96; P = .02) and 91% (CI: 0.80–0.97; P = .01). The pooled data showed that diagnostic odds ratio (DOR) of DKI was 79.75 (CI: 31.57–201.45). The area under the curve (AUC) of summary receiver operating characteristic curve was 0.96. There is no evidence that our research has a threshold effect (Spearman correlation coefficient: 0.300, P = .624) and publication bias. Meta regression analysis identified that country, language, field strength, and parameter of magnetic resonance imaging had no significant effect on diagnostic performance. CONCLUSION: The present meta-analysis shows that the mean kurtosis values derived from DKI may be useful in characterization of gliomas with high sensitivity and specificity. Taken into consideration the small sample of this study, we need to be cautious when interpreting the results of this study. Wolters Kluwer Health 2018-11-02 /pmc/articles/PMC6221635/ /pubmed/30383687 http://dx.doi.org/10.1097/MD.0000000000013068 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Huang, Ruiyu
Chen, Yanni
Li, Wenfei
Zhang, Xvfeng
An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
title An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
title_full An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
title_fullStr An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
title_full_unstemmed An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
title_short An evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
title_sort evidence-based approach to assess the accuracy of diffusion kurtosis imaging in characterization of gliomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221635/
https://www.ncbi.nlm.nih.gov/pubmed/30383687
http://dx.doi.org/10.1097/MD.0000000000013068
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