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Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article
The aim of the study was to assess the independent contribution of hyperuricemia to coronary artery disease (CAD) confirmed by coronary angiography (CAG), and to explore associations between serum uric acid (SUA) level and CAD. We performed a retrospective cohort study of 5069 patients who underwent...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221642/ https://www.ncbi.nlm.nih.gov/pubmed/30383640 http://dx.doi.org/10.1097/MD.0000000000012926 |
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author | Lan, Ming Liu, Bing He, Qing |
author_facet | Lan, Ming Liu, Bing He, Qing |
author_sort | Lan, Ming |
collection | PubMed |
description | The aim of the study was to assess the independent contribution of hyperuricemia to coronary artery disease (CAD) confirmed by coronary angiography (CAG), and to explore associations between serum uric acid (SUA) level and CAD. We performed a retrospective cohort study of 5069 patients who underwent CAG. Patients were divided into groups: hyperuricemia (n = 1178) versus nonhyperuricemia (n = 3891) and CAD (n = 3433) versus non-CAD (n = 1636). The incidence of CAD was higher in the hyperuricemia group than in the nonhyperuricemia group (71.5% vs 66.6%, P = .002). Hyperuricemia and CAD were significantly correlated in women (odds ratio = 1.509, 95% confidence interval, 1.106–2.057, P = .009). And there were trends, higher SUA quartiles were associated with higher percentage of CAD (62.3%, 68.0%, 68.9%, and 71.7% for quartiles 1, 2, 3, and 4, respectively, P < .001), and the incidence of 3-vessel disease increased (25.2%, 26.4%, 27.2%, and 31.1% for quartiles 1, 2, 3, and 4, respectively, P = .001) and that of normal vessel decreased (37.7%, 32.0%, 31.1%, and 28.3% for quartiles 1, 2, 3, and 4, respectively, P < .001) across quartiles, these trends were found in female group, but not in male group. The SUA level significantly increased as the number of diseased vessels increased (P < .001). There was an independent correlation between hyperuricemia and CAD in women. A higher SUA level was associated with a higher incidence of 3-vessel disease in women. |
format | Online Article Text |
id | pubmed-6221642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-62216422018-12-04 Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article Lan, Ming Liu, Bing He, Qing Medicine (Baltimore) Research Article The aim of the study was to assess the independent contribution of hyperuricemia to coronary artery disease (CAD) confirmed by coronary angiography (CAG), and to explore associations between serum uric acid (SUA) level and CAD. We performed a retrospective cohort study of 5069 patients who underwent CAG. Patients were divided into groups: hyperuricemia (n = 1178) versus nonhyperuricemia (n = 3891) and CAD (n = 3433) versus non-CAD (n = 1636). The incidence of CAD was higher in the hyperuricemia group than in the nonhyperuricemia group (71.5% vs 66.6%, P = .002). Hyperuricemia and CAD were significantly correlated in women (odds ratio = 1.509, 95% confidence interval, 1.106–2.057, P = .009). And there were trends, higher SUA quartiles were associated with higher percentage of CAD (62.3%, 68.0%, 68.9%, and 71.7% for quartiles 1, 2, 3, and 4, respectively, P < .001), and the incidence of 3-vessel disease increased (25.2%, 26.4%, 27.2%, and 31.1% for quartiles 1, 2, 3, and 4, respectively, P = .001) and that of normal vessel decreased (37.7%, 32.0%, 31.1%, and 28.3% for quartiles 1, 2, 3, and 4, respectively, P < .001) across quartiles, these trends were found in female group, but not in male group. The SUA level significantly increased as the number of diseased vessels increased (P < .001). There was an independent correlation between hyperuricemia and CAD in women. A higher SUA level was associated with a higher incidence of 3-vessel disease in women. Wolters Kluwer Health 2018-11-02 /pmc/articles/PMC6221642/ /pubmed/30383640 http://dx.doi.org/10.1097/MD.0000000000012926 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Lan, Ming Liu, Bing He, Qing Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article |
title | Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article |
title_full | Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article |
title_fullStr | Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article |
title_full_unstemmed | Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article |
title_short | Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article |
title_sort | evaluation of the association between hyperuricemia and coronary artery disease: a strobe-compliant article |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221642/ https://www.ncbi.nlm.nih.gov/pubmed/30383640 http://dx.doi.org/10.1097/MD.0000000000012926 |
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