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Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and (18)F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221745/ https://www.ncbi.nlm.nih.gov/pubmed/30412075 http://dx.doi.org/10.1097/MD.0000000000012840 |
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author | Lee, Soo Jin Chung, Min Sung Shin, Su-Jin Choi, Yun Young |
author_facet | Lee, Soo Jin Chung, Min Sung Shin, Su-Jin Choi, Yun Young |
author_sort | Lee, Soo Jin |
collection | PubMed |
description | Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and (18)F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUV(max)) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUV(max) (r = 0.520, P < .001). Both TBR and SUV(max) were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUV(max) of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUV(max) were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis. |
format | Online Article Text |
id | pubmed-6221745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-62217452018-12-04 Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer Lee, Soo Jin Chung, Min Sung Shin, Su-Jin Choi, Yun Young Medicine (Baltimore) Research Article Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and (18)F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUV(max)) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUV(max) (r = 0.520, P < .001). Both TBR and SUV(max) were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUV(max) of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUV(max) were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis. Wolters Kluwer Health 2018-10-26 /pmc/articles/PMC6221745/ /pubmed/30412075 http://dx.doi.org/10.1097/MD.0000000000012840 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Research Article Lee, Soo Jin Chung, Min Sung Shin, Su-Jin Choi, Yun Young Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer |
title | Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer |
title_full | Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer |
title_fullStr | Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer |
title_full_unstemmed | Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer |
title_short | Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer |
title_sort | correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose pet/ct with molecular subtypes of breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221745/ https://www.ncbi.nlm.nih.gov/pubmed/30412075 http://dx.doi.org/10.1097/MD.0000000000012840 |
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