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Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer

Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and (18)F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelati...

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Autores principales: Lee, Soo Jin, Chung, Min Sung, Shin, Su-Jin, Choi, Yun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221745/
https://www.ncbi.nlm.nih.gov/pubmed/30412075
http://dx.doi.org/10.1097/MD.0000000000012840
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author Lee, Soo Jin
Chung, Min Sung
Shin, Su-Jin
Choi, Yun Young
author_facet Lee, Soo Jin
Chung, Min Sung
Shin, Su-Jin
Choi, Yun Young
author_sort Lee, Soo Jin
collection PubMed
description Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and (18)F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUV(max)) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUV(max) (r = 0.520, P < .001). Both TBR and SUV(max) were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUV(max) of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUV(max) were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis.
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spelling pubmed-62217452018-12-04 Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer Lee, Soo Jin Chung, Min Sung Shin, Su-Jin Choi, Yun Young Medicine (Baltimore) Research Article Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and (18)F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUV(max)) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUV(max) (r = 0.520, P < .001). Both TBR and SUV(max) were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUV(max) of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUV(max) were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis. Wolters Kluwer Health 2018-10-26 /pmc/articles/PMC6221745/ /pubmed/30412075 http://dx.doi.org/10.1097/MD.0000000000012840 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Lee, Soo Jin
Chung, Min Sung
Shin, Su-Jin
Choi, Yun Young
Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
title Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
title_full Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
title_fullStr Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
title_full_unstemmed Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
title_short Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer
title_sort correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose pet/ct with molecular subtypes of breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221745/
https://www.ncbi.nlm.nih.gov/pubmed/30412075
http://dx.doi.org/10.1097/MD.0000000000012840
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