Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game

The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order...

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Detalles Bibliográficos
Autores principales: Sharma, Anamika, El-Faham, Ayman, de la Torre, Beatriz G., Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221914/
https://www.ncbi.nlm.nih.gov/pubmed/30443543
http://dx.doi.org/10.3389/fchem.2018.00516
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author Sharma, Anamika
El-Faham, Ayman
de la Torre, Beatriz G.
Albericio, Fernando
author_facet Sharma, Anamika
El-Faham, Ayman
de la Torre, Beatriz G.
Albericio, Fernando
author_sort Sharma, Anamika
collection PubMed
description The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order for incorporating nucleophiles in TCT was found to be alcohol > thiol > amine.
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spelling pubmed-62219142018-11-15 Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game Sharma, Anamika El-Faham, Ayman de la Torre, Beatriz G. Albericio, Fernando Front Chem Chemistry The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order for incorporating nucleophiles in TCT was found to be alcohol > thiol > amine. Frontiers Media S.A. 2018-11-01 /pmc/articles/PMC6221914/ /pubmed/30443543 http://dx.doi.org/10.3389/fchem.2018.00516 Text en Copyright © 2018 Sharma, El-Faham, de la Torre and Albericio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Sharma, Anamika
El-Faham, Ayman
de la Torre, Beatriz G.
Albericio, Fernando
Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game
title Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game
title_full Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game
title_fullStr Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game
title_full_unstemmed Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game
title_short Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game
title_sort exploring the orthogonal chemoselectivity of 2,4,6-trichloro-1,3,5-triazine (tct) as a trifunctional linker with different nucleophiles: rules of the game
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221914/
https://www.ncbi.nlm.nih.gov/pubmed/30443543
http://dx.doi.org/10.3389/fchem.2018.00516
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