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Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces

Factor H (FH) is the major regulator of C3b in the alternative pathway of the complement system in immunity. FH comprises 20 short complement regulator (SCR) domains, including eight glycans, and its Y402H polymorphism predisposes those who carry it to age-related macular degeneration. To better und...

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Detalles Bibliográficos
Autores principales:	Osborne, Amy J., Miller, Ami, Bhatt, Jayesh S., Gor, Jayesh, Perkins, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222095/ https://www.ncbi.nlm.nih.gov/pubmed/30217822 http://dx.doi.org/10.1074/jbc.RA118.004767

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