Cargando…

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency

The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir. Hence, alternative approaches, such as permanent blocking of viral transcript...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kyei, George B., Meng, Shanshan, Ramani, Rashmi, Niu, Austin, Lagisetti, Chandraiah, Webb, Thomas R., Ratner, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222122/ https://www.ncbi.nlm.nih.gov/pubmed/30401776 http://dx.doi.org/10.1128/mBio.01423-18

Ejemplares similares

Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency
por: Heffern, Elleard FW, et al.
Publicado: (2019)

The transcriptional transactivator Tat selectively regulates viral splicing
por: Jablonski, Joseph A., et al.
Publicado: (2010)

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency
por: Mousseau, Guillaume, et al.
Publicado: (2015)

Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates
por: Shi, Yihui, et al.
Publicado: (2015)

Sudemycin E influences alternative splicing and changes chromatin modifications
por: Convertini, Paolo, et al.
Publicado: (2014)

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications
por: Shi, Yihui, et al.
Publicado: (2020)

Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency
por: Jean, Maxime Junior, et al.
Publicado: (2017)

HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations
por: Kamori, Doreen, et al.
Publicado: (2017)

Herpesviruses: latency and reactivation – viral strategies and host response
por: Grinde, Bjørn
Publicado: (2013)

A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
por: Depledge, Daniel P., et al.
Publicado: (2018)

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
por: Xargay-Torrent, Sílvia, et al.
Publicado: (2015)

Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation
por: Kong, Weili, et al.
Publicado: (2020)

Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
por: James, Stephanie F., et al.
Publicado: (2012)

Establishment of an In Vitro Model of Pseudorabies Virus Latency and Reactivation and Identification of Key Viral Latency-Associated Genes
por: Pan, Li, et al.
Publicado: (2023)

HIV latency reversing agents act through Tat post translational modifications
por: Khoury, Georges, et al.
Publicado: (2018)

A truncated HIV Tat demonstrates potent and specific latency reversal activity
por: Van Gulck, Ellen, et al.
Publicado: (2023)

NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter
por: Kim, Hye-Young, et al.
Publicado: (2014)

Herpes Simplex Virus Type 2 Triggers Reactivation of Kaposi's Sarcoma-Associated Herpesvirus from Latency and Collaborates with HIV-1 Tat
por: Tang, Qiao, et al.
Publicado: (2012)

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation
por: Albert, Brice J., et al.
Publicado: (2017)

Substrate-gated docking of pore subunit Tha4 in the TatC cavity initiates Tat translocase assembly
por: Aldridge, Cassie, et al.
Publicado: (2014)

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation
por: Ma, Jilei, et al.
Publicado: (2017)

Relevance of multiply spliced HIV-1 RNA measurement in assessing the efficacy of viral latency-reversing strategies
por: Doria, Margherita
Publicado: (2021)

Tat-SF1 Is Not Required for Tat Transactivation but Does Regulate the Relative Levels of Unspliced and Spliced HIV-1 RNAs
por: Miller, Heather B., et al.
Publicado: (2009)

A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency
por: Poole, Emma L., et al.
Publicado: (2018)

Fluctuations in Tat copy number when it counts the most: a possible mechanism to battle the HIV latency
por: Konkoli, Zoran, et al.
Publicado: (2013)

Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency
por: Geng, Guannan, et al.
Publicado: (2016)

Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation
por: Li, Jun, et al.
Publicado: (2016)

Epigenetic Control of Cytomegalovirus Latency and Reactivation
por: Liu, Xue-feng, et al.
Publicado: (2013)

Regulation of KSHV Latency and Lytic Reactivation
por: Broussard, Grant, et al.
Publicado: (2020)

UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat
por: Liang, Taizhen, et al.
Publicado: (2021)

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency
por: Pasternak, Alexander O., et al.
Publicado: (2023)

Effects of thyroid hormone on HSV-1 gene regulation: implications in the control of viral latency and reactivation
por: Hsia, Shao-Chung, et al.
Publicado: (2011)

HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation
por: Diggins, Nicole L., et al.
Publicado: (2018)

Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR
por: Van Duyne, Rachel, et al.
Publicado: (2008)

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease
por: Beylkin, Diane, et al.
Publicado: (2017)

Dynamic models of viral replication and latency
por: Mohammadi, Pejman, et al.
Publicado: (2015)

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency
por: Pasternak, Alexander O., et al.
Publicado: (2023)

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter
por: Wu, Jun, et al.
Publicado: (2017)

Epigenetic modification of the Epstein-Barr virus BZLF1 promoter regulates viral reactivation from latency
por: Murata, Takayuki, et al.
Publicado: (2013)

Preferential selection of viral escape mutants by CD8(+) T cell ‘sieving’ of SIV reactivation from latency
por: Docken, Steffen S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pj4ukj9lb13862cs36b02qoihf