Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228

FK228 is an FDA-approved anticancer drug naturally produced by Chromobacterium violaceum No. 968 up to 19 mg/L in a pilot industry-scale batch fermentation. Here we report a genomics-guided discovery of Burkholderia thailandensis MSMB43 as a new and significantly better source of FK228. The genome o...

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Detalles Bibliográficos
Autores principales: Liu, Xiangyang, Xie, Feng, Doughty, Leah B., Wang, Qi, Zhang, Lixin, Liu, Xueting, Cheng, Yi-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222137/
https://www.ncbi.nlm.nih.gov/pubmed/30417143
http://dx.doi.org/10.1016/j.synbio.2018.10.011

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