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Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization expos...

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Autores principales: Wattanathorn, Jintanaporn, Prabsattroo, Thawatchai, Somsapt, Pichet, Sritragool, Opass, Thukham-mee, Wipawee, Muchimapura, Supaporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222230/
https://www.ncbi.nlm.nih.gov/pubmed/30498760
http://dx.doi.org/10.1155/2018/6452965
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author Wattanathorn, Jintanaporn
Prabsattroo, Thawatchai
Somsapt, Pichet
Sritragool, Opass
Thukham-mee, Wipawee
Muchimapura, Supaporn
author_facet Wattanathorn, Jintanaporn
Prabsattroo, Thawatchai
Somsapt, Pichet
Sritragool, Opass
Thukham-mee, Wipawee
Muchimapura, Supaporn
author_sort Wattanathorn, Jintanaporn
collection PubMed
description In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. All doses of extract improved male sexual behaviors, suppressed MAO-B in NAc, enhanced TH-positive cells density in NAc, suppressed PDE-5 in penis, and enhanced interstitial cell of Leydig. The increase of serum testosterone, TH-positive cells density in VTA, eNOS expression in penis, and the decreased serum corticosterone were observed at some doses. Therefore, the sexual enhancing effect of extract occurred mainly via the improved dopaminergic and testicular functions. PDE-5 suppression in penis also played the role especially in the increased intromission behavior. Therefore, A. occidentale leaves extract is the potential protective agent against sexual dysfunction. However, further researches are necessary.
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spelling pubmed-62222302018-11-29 Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions Wattanathorn, Jintanaporn Prabsattroo, Thawatchai Somsapt, Pichet Sritragool, Opass Thukham-mee, Wipawee Muchimapura, Supaporn Biomed Res Int Research Article In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. All doses of extract improved male sexual behaviors, suppressed MAO-B in NAc, enhanced TH-positive cells density in NAc, suppressed PDE-5 in penis, and enhanced interstitial cell of Leydig. The increase of serum testosterone, TH-positive cells density in VTA, eNOS expression in penis, and the decreased serum corticosterone were observed at some doses. Therefore, the sexual enhancing effect of extract occurred mainly via the improved dopaminergic and testicular functions. PDE-5 suppression in penis also played the role especially in the increased intromission behavior. Therefore, A. occidentale leaves extract is the potential protective agent against sexual dysfunction. However, further researches are necessary. Hindawi 2018-10-25 /pmc/articles/PMC6222230/ /pubmed/30498760 http://dx.doi.org/10.1155/2018/6452965 Text en Copyright © 2018 Jintanaporn Wattanathorn et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wattanathorn, Jintanaporn
Prabsattroo, Thawatchai
Somsapt, Pichet
Sritragool, Opass
Thukham-mee, Wipawee
Muchimapura, Supaporn
Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
title Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
title_full Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
title_fullStr Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
title_full_unstemmed Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
title_short Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions
title_sort sexual enhancing effect of anacardium occidentale in stress-exposed rats by improving dopaminergic and testicular functions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222230/
https://www.ncbi.nlm.nih.gov/pubmed/30498760
http://dx.doi.org/10.1155/2018/6452965
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