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Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy

Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and en...

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Detalles Bibliográficos
Autores principales: Matsushita, Maiko, Kawaguchi, Mai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222238/
https://www.ncbi.nlm.nih.gov/pubmed/30498512
http://dx.doi.org/10.1155/2018/8653489
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author Matsushita, Maiko
Kawaguchi, Mai
author_facet Matsushita, Maiko
Kawaguchi, Mai
author_sort Matsushita, Maiko
collection PubMed
description Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. There have been several reports on the immune-modulatory effects of commonly used drugs, namely, statin, metformin, and angiotensin receptor blockers (ARBs), which suggest that these drugs could enhance immunity against cancer cells. Other anticancer drugs, such as anthracyclines, thalidomides, lenalidomides, and hypomethylating drugs, could also strengthen the immune system to attack cancer cells at a relatively low dose. Hence, these drugs might contribute to better outcomes in cancer patients.
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spelling pubmed-62222382018-11-29 Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy Matsushita, Maiko Kawaguchi, Mai J Oncol Review Article Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. There have been several reports on the immune-modulatory effects of commonly used drugs, namely, statin, metformin, and angiotensin receptor blockers (ARBs), which suggest that these drugs could enhance immunity against cancer cells. Other anticancer drugs, such as anthracyclines, thalidomides, lenalidomides, and hypomethylating drugs, could also strengthen the immune system to attack cancer cells at a relatively low dose. Hence, these drugs might contribute to better outcomes in cancer patients. Hindawi 2018-10-25 /pmc/articles/PMC6222238/ /pubmed/30498512 http://dx.doi.org/10.1155/2018/8653489 Text en Copyright © 2018 Maiko Matsushita and Mai Kawaguchi. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Matsushita, Maiko
Kawaguchi, Mai
Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
title Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
title_full Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
title_fullStr Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
title_full_unstemmed Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
title_short Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
title_sort immunomodulatory effects of drugs for effective cancer immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222238/
https://www.ncbi.nlm.nih.gov/pubmed/30498512
http://dx.doi.org/10.1155/2018/8653489
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