Mesenchymal stromal cells as a potential therapeutic for neurological disorders()

Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore neurological damage through their secretion of paracrine factors or their differentiation to neuronal cells. Based on these studies, many clinical trials have been conducted using MSCs for neurological disorders, and th...

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Detalles Bibliográficos
Autores principales: Mukai, Takeo, Tojo, Arinobu, Nagamura-Inoue, Tokiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222283/
https://www.ncbi.nlm.nih.gov/pubmed/30525073
http://dx.doi.org/10.1016/j.reth.2018.08.001
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author Mukai, Takeo
Tojo, Arinobu
Nagamura-Inoue, Tokiko
author_facet Mukai, Takeo
Tojo, Arinobu
Nagamura-Inoue, Tokiko
author_sort Mukai, Takeo
collection PubMed
description Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore neurological damage through their secretion of paracrine factors or their differentiation to neuronal cells. Based on these studies, many clinical trials have been conducted using MSCs for neurological disorders, and their safety and efficacy have been reported. In this review, we provide a brief introduction to MSCs, especially umbilical cord derived-MSCs (UC-MSCs), in terms of characteristics, isolation, and cryopreservation, and discuss the recent progress in regenerative therapies using MSCs for various neurological disorders.
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spelling pubmed-62222832018-12-06 Mesenchymal stromal cells as a potential therapeutic for neurological disorders() Mukai, Takeo Tojo, Arinobu Nagamura-Inoue, Tokiko Regen Ther Review Article Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore neurological damage through their secretion of paracrine factors or their differentiation to neuronal cells. Based on these studies, many clinical trials have been conducted using MSCs for neurological disorders, and their safety and efficacy have been reported. In this review, we provide a brief introduction to MSCs, especially umbilical cord derived-MSCs (UC-MSCs), in terms of characteristics, isolation, and cryopreservation, and discuss the recent progress in regenerative therapies using MSCs for various neurological disorders. Japanese Society for Regenerative Medicine 2018-08-24 /pmc/articles/PMC6222283/ /pubmed/30525073 http://dx.doi.org/10.1016/j.reth.2018.08.001 Text en © 2018 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Mukai, Takeo
Tojo, Arinobu
Nagamura-Inoue, Tokiko
Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
title Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
title_full Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
title_fullStr Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
title_full_unstemmed Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
title_short Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
title_sort mesenchymal stromal cells as a potential therapeutic for neurological disorders()
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222283/
https://www.ncbi.nlm.nih.gov/pubmed/30525073
http://dx.doi.org/10.1016/j.reth.2018.08.001
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