Binding of Drug-Activated CAR/Nr1i3 Alters Metabolic Regulation in the Liver

The constitutive androstane receptor (CAR/Nr1i3) regulates detoxification of drugs and other xenobiotics by the liver. Binding of these compounds, activating ligands, causes CAR to translocate to the nucleus and stimulate genes of detoxification. However, CAR activation also changes metabolism and i...

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Detalles Bibliográficos
Autores principales: Tian, Jianmin, Marino, Rebecca, Johnson, Carla, Locker, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222290/
https://www.ncbi.nlm.nih.gov/pubmed/30396153
http://dx.doi.org/10.1016/j.isci.2018.10.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222290/
https://www.ncbi.nlm.nih.gov/pubmed/30396153
http://dx.doi.org/10.1016/j.isci.2018.10.018

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