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Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology

Carbohydrate analyses are often challenging due to the structural complexity of these molecules, as well as the lack of suitable analytical tools for distinguishing the vast number of possible isomers. The coupled technique, ion mobility-mass spectrometry (IM-MS), has been in use for two decades for...

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Detalles Bibliográficos
Autores principales: Mu, Yuqing, Schulz, Benjamin L., Ferro, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222328/
https://www.ncbi.nlm.nih.gov/pubmed/30301275
http://dx.doi.org/10.3390/molecules23102557
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author Mu, Yuqing
Schulz, Benjamin L.
Ferro, Vito
author_facet Mu, Yuqing
Schulz, Benjamin L.
Ferro, Vito
author_sort Mu, Yuqing
collection PubMed
description Carbohydrate analyses are often challenging due to the structural complexity of these molecules, as well as the lack of suitable analytical tools for distinguishing the vast number of possible isomers. The coupled technique, ion mobility-mass spectrometry (IM-MS), has been in use for two decades for the analysis of complex biomolecules, and in recent years it has emerged as a powerful technique for the analysis of carbohydrates. For carbohydrates, most studies have focused on the separation and characterization of isomers in biological samples. IM-MS is capable of separating isomeric ions by drift time, and further characterizing them by mass analysis. Applications of IM-MS in carbohydrate analysis are extremely useful and important for understanding many biological mechanisms and for the determination of disease states, although efforts are still needed for higher sensitivity and resolution.
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spelling pubmed-62223282018-11-13 Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology Mu, Yuqing Schulz, Benjamin L. Ferro, Vito Molecules Review Carbohydrate analyses are often challenging due to the structural complexity of these molecules, as well as the lack of suitable analytical tools for distinguishing the vast number of possible isomers. The coupled technique, ion mobility-mass spectrometry (IM-MS), has been in use for two decades for the analysis of complex biomolecules, and in recent years it has emerged as a powerful technique for the analysis of carbohydrates. For carbohydrates, most studies have focused on the separation and characterization of isomers in biological samples. IM-MS is capable of separating isomeric ions by drift time, and further characterizing them by mass analysis. Applications of IM-MS in carbohydrate analysis are extremely useful and important for understanding many biological mechanisms and for the determination of disease states, although efforts are still needed for higher sensitivity and resolution. MDPI 2018-10-07 /pmc/articles/PMC6222328/ /pubmed/30301275 http://dx.doi.org/10.3390/molecules23102557 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mu, Yuqing
Schulz, Benjamin L.
Ferro, Vito
Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
title Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
title_full Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
title_fullStr Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
title_full_unstemmed Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
title_short Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
title_sort applications of ion mobility-mass spectrometry in carbohydrate chemistry and glycobiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222328/
https://www.ncbi.nlm.nih.gov/pubmed/30301275
http://dx.doi.org/10.3390/molecules23102557
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