Cargando…

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic system in the brain. Cholinesterase (ChE) inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hussein, Weiam, Sağlık, Begüm Nurpelin, Levent, Serkan, Korkut, Büşra, Ilgın, Sinem, Özkay, Yusuf, Kaplancıklı, Zafer Asım
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222329/ https://www.ncbi.nlm.nih.gov/pubmed/30110946 http://dx.doi.org/10.3390/molecules23082033

Ejemplares similares

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
por: Karaca, Şevval, et al.
Publicado: (2022)

Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
por: Ilgın, Sinem, et al.
Publicado: (2017)

Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
por: Kaplancıklı, Zafer Asım, et al.
Publicado: (2017)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Design, Synthesis, and Structure–Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer’s Disease
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors
por: Haji Ali, Sazan, et al.
Publicado: (2022)

Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2022)

Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Novel Thiosemicarbazone Derivatives: In Vitro and In Silico Evaluation as Potential MAO-B Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2021)

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
por: Kaya, Betül, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation Studies of Novel Naphthalene-Chalcone Hybrids As Antimicrobial, Anticandidal, Anticancer, and VEGFR-2 Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2023)

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
por: Acar Cevik, Ulviye, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
por: Çavuşoğlu, Betül Kaya, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
por: Turan-Zitouni, Gülhan, et al.
Publicado: (2018)

Synthesis, Antifungal Activities, Molecular Docking and Molecular Dynamic Studies of Novel Quinoxaline-Triazole Compounds
por: Osmaniye, Derya, et al.
Publicado: (2023)

Synthesis and Anticandidal Activity of New Imidazole-Chalcones
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
por: Levent, Serkan, et al.
Publicado: (2017)

Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
por: Osmaniye, Derya, et al.
Publicado: (2019)

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2019)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2018)

Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor
por: Çevik, Ulviye Acar, et al.
Publicado: (2022)

Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
por: Çevik, Ulviye Acar, et al.
Publicado: (2017)

Investigation of Novel Quinoline–Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches
por: Evren, Asaf Evrim, et al.
Publicado: (2022)

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

Synthesis and Molecular Docking of New N-Acyl Hydrazones-Benzimidazole as hCA I and II Inhibitors
por: Küçükoğlu, Kaan, et al.
Publicado: (2023)

Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2014)

The 4-(dimethylaminoalkyl)piperazine inhibitors of α-glucosidase: allosteric enzyme inhibition and identification of interacting chemical groups
por: GHANI, Usman, et al.
Publicado: (2022)

Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents
por: Kaplancikli, Zafer Asim
Publicado: (2011)

Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
por: Tokgöz, Gamze, et al.
Publicado: (2018)

Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
por: Güzel, Emir, et al.
Publicado: (2023)

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
por: Özdemir, Ahmet, et al.
Publicado: (2015)

Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole–Thiadiazole Hybrids
por: Celik, Ismail, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_21f9masfbtlfj8b3gj0q6vh8np