New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity

Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configuration...

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Detalles Bibliográficos
Autores principales: Bao, Jie, He, Fei, Yu, Jin-Hai, Zhai, Huijuan, Cheng, Zhi-Qiang, Jiang, Cheng-Shi, Zhang, Yuying, Zhang, Yun, Zhang, Xiaoyong, Chen, Guangying, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222336/
https://www.ncbi.nlm.nih.gov/pubmed/30096887
http://dx.doi.org/10.3390/molecules23081982
Descripción
Sumario:Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC(50) values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM.

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