Meliacarpinin-Type Limonoids from the Bark of Melia toosendan

Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, m...

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Detalles Bibliográficos
Autores principales: Hu, Yalin, Heng, Li, Xu, Rong, Li, Junhe, Wei, Shanshan, Xu, Deran, Luo, Jun, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222421/
https://www.ncbi.nlm.nih.gov/pubmed/30308969
http://dx.doi.org/10.3390/molecules23102590
Descripción
Sumario:Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher’s method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages.

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