Meliacarpinin-Type Limonoids from the Bark of Melia toosendan

Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, m...

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Autores principales: Hu, Yalin, Heng, Li, Xu, Rong, Li, Junhe, Wei, Shanshan, Xu, Deran, Luo, Jun, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222421/
https://www.ncbi.nlm.nih.gov/pubmed/30308969
http://dx.doi.org/10.3390/molecules23102590
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author Hu, Yalin
Heng, Li
Xu, Rong
Li, Junhe
Wei, Shanshan
Xu, Deran
Luo, Jun
Li, Yi
author_facet Hu, Yalin
Heng, Li
Xu, Rong
Li, Junhe
Wei, Shanshan
Xu, Deran
Luo, Jun
Li, Yi
author_sort Hu, Yalin
collection PubMed
description Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher’s method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages.
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spelling pubmed-62224212018-11-13 Meliacarpinin-Type Limonoids from the Bark of Melia toosendan Hu, Yalin Heng, Li Xu, Rong Li, Junhe Wei, Shanshan Xu, Deran Luo, Jun Li, Yi Molecules Article Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher’s method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages. MDPI 2018-10-10 /pmc/articles/PMC6222421/ /pubmed/30308969 http://dx.doi.org/10.3390/molecules23102590 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Yalin
Heng, Li
Xu, Rong
Li, Junhe
Wei, Shanshan
Xu, Deran
Luo, Jun
Li, Yi
Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
title Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
title_full Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
title_fullStr Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
title_full_unstemmed Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
title_short Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
title_sort meliacarpinin-type limonoids from the bark of melia toosendan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222421/
https://www.ncbi.nlm.nih.gov/pubmed/30308969
http://dx.doi.org/10.3390/molecules23102590
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