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Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study

Human G-protein coupled receptors (GPCRs) are important targets for pharmaceutical intervention against neurological diseases. Here, we use molecular simulation to investigate the key step in ligand recognition governed by the extracellular domains in the neuronal adenosine receptor type 2A (hA(2A)R...

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Detalles Bibliográficos
Autores principales:	Cao, Ruyin, Giorgetti, Alejandro, Bauer, Andreas, Neumaier, Bernd, Rossetti, Giulia, Carloni, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222423/ https://www.ncbi.nlm.nih.gov/pubmed/30322034 http://dx.doi.org/10.3390/molecules23102616

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