Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3

Tumor suppressor p53-directed apoptosis triggers loss of normal cells, which contributes to the side-effects from anticancer therapies. Thus, small molecules with potential to downregulate the activation of p53 could minimize pathology emerging from anticancer therapies. Acetylation of p53 by the hi...

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Detalles Bibliográficos
Autores principales: Vincek, Adam S., Patel, Jigneshkumar, Jaganathan, Anbalagan, Green, Antonia, Pierre-Louis, Valerie, Arora, Vimal, Rehmann, Jill, Mezei, Mihaly, Zhou, Ming-Ming, Ohlmeyer, Michael, Mujtaba, Shiraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222455/
https://www.ncbi.nlm.nih.gov/pubmed/30072621
http://dx.doi.org/10.3390/molecules23081930

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