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NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na(V) Channel Potency

μ-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of μ-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations. Despite high sequence similarity, GIIIC adopts a three-dimensional...

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Detalles Bibliográficos
Autores principales:	Harvey, Peta J., Kurniawan, Nyoman D., Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Van Lysebetten, Dorien, Dash, Thomas S., Hill, Justine M., Adams, David J., Durek, Thomas, Craik, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222493/ https://www.ncbi.nlm.nih.gov/pubmed/30360356 http://dx.doi.org/10.3390/molecules23102715

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