Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

Quercetagetin and patuletin were extracted by the same method from two different Tagetes species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC(50) and necrotic, apoptotic and selective activities of thes...

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Autores principales: Alvarado-Sansininea, Jesús J., Sánchez-Sánchez, Luis, López-Muñoz, Hugo, Escobar, María L., Flores-Guzmán, Fernando, Tavera-Hernández, Rosario, Jiménez-Estrada, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222523/
https://www.ncbi.nlm.nih.gov/pubmed/30304821
http://dx.doi.org/10.3390/molecules23102579
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author Alvarado-Sansininea, Jesús J.
Sánchez-Sánchez, Luis
López-Muñoz, Hugo
Escobar, María L.
Flores-Guzmán, Fernando
Tavera-Hernández, Rosario
Jiménez-Estrada, Manuel
author_facet Alvarado-Sansininea, Jesús J.
Sánchez-Sánchez, Luis
López-Muñoz, Hugo
Escobar, María L.
Flores-Guzmán, Fernando
Tavera-Hernández, Rosario
Jiménez-Estrada, Manuel
author_sort Alvarado-Sansininea, Jesús J.
collection PubMed
description Quercetagetin and patuletin were extracted by the same method from two different Tagetes species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC(50) and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency.
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spelling pubmed-62225232018-11-13 Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines Alvarado-Sansininea, Jesús J. Sánchez-Sánchez, Luis López-Muñoz, Hugo Escobar, María L. Flores-Guzmán, Fernando Tavera-Hernández, Rosario Jiménez-Estrada, Manuel Molecules Article Quercetagetin and patuletin were extracted by the same method from two different Tagetes species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC(50) and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency. MDPI 2018-10-09 /pmc/articles/PMC6222523/ /pubmed/30304821 http://dx.doi.org/10.3390/molecules23102579 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alvarado-Sansininea, Jesús J.
Sánchez-Sánchez, Luis
López-Muñoz, Hugo
Escobar, María L.
Flores-Guzmán, Fernando
Tavera-Hernández, Rosario
Jiménez-Estrada, Manuel
Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines
title Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines
title_full Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines
title_fullStr Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines
title_full_unstemmed Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines
title_short Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines
title_sort quercetagetin and patuletin: antiproliferative, necrotic and apoptotic activity in tumor cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222523/
https://www.ncbi.nlm.nih.gov/pubmed/30304821
http://dx.doi.org/10.3390/molecules23102579
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