Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization

Azaindoles are rare in nature but extremely attractive for drug discovery programs. Azaindoles can be obtained by diverse methods, including those involving metal-catalyzed reactions. This important core has been fascinating the scientific community due to their challenging synthesis and relevant bi...

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Detalles Bibliográficos
Autores principales: Santos, A. Sofia, Mortinho, Ana C., Marques, M. Manuel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222529/
https://www.ncbi.nlm.nih.gov/pubmed/30336623
http://dx.doi.org/10.3390/molecules23102673
Descripción
Sumario:Azaindoles are rare in nature but extremely attractive for drug discovery programs. Azaindoles can be obtained by diverse methods, including those involving metal-catalyzed reactions. This important core has been fascinating the scientific community due to their challenging synthesis and relevant bioactivity. This paper highlights the diverse synthetic methodologies developed to date involving metal-catalyzed reaction to attain azaindoles and its functionalization.

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