Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization

Azaindoles are rare in nature but extremely attractive for drug discovery programs. Azaindoles can be obtained by diverse methods, including those involving metal-catalyzed reactions. This important core has been fascinating the scientific community due to their challenging synthesis and relevant bi...

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Detalles Bibliográficos
Autores principales: Santos, A. Sofia, Mortinho, Ana C., Marques, M. Manuel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222529/
https://www.ncbi.nlm.nih.gov/pubmed/30336623
http://dx.doi.org/10.3390/molecules23102673
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author Santos, A. Sofia
Mortinho, Ana C.
Marques, M. Manuel B.
author_facet Santos, A. Sofia
Mortinho, Ana C.
Marques, M. Manuel B.
author_sort Santos, A. Sofia
collection PubMed
description Azaindoles are rare in nature but extremely attractive for drug discovery programs. Azaindoles can be obtained by diverse methods, including those involving metal-catalyzed reactions. This important core has been fascinating the scientific community due to their challenging synthesis and relevant bioactivity. This paper highlights the diverse synthetic methodologies developed to date involving metal-catalyzed reaction to attain azaindoles and its functionalization.
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spelling pubmed-62225292018-11-13 Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization Santos, A. Sofia Mortinho, Ana C. Marques, M. Manuel B. Molecules Review Azaindoles are rare in nature but extremely attractive for drug discovery programs. Azaindoles can be obtained by diverse methods, including those involving metal-catalyzed reactions. This important core has been fascinating the scientific community due to their challenging synthesis and relevant bioactivity. This paper highlights the diverse synthetic methodologies developed to date involving metal-catalyzed reaction to attain azaindoles and its functionalization. MDPI 2018-10-17 /pmc/articles/PMC6222529/ /pubmed/30336623 http://dx.doi.org/10.3390/molecules23102673 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Santos, A. Sofia
Mortinho, Ana C.
Marques, M. Manuel B.
Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization
title Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization
title_full Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization
title_fullStr Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization
title_full_unstemmed Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization
title_short Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization
title_sort metal-catalyzed cross-coupling reactions on azaindole synthesis and functionalization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222529/
https://www.ncbi.nlm.nih.gov/pubmed/30336623
http://dx.doi.org/10.3390/molecules23102673
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AT mortinhoanac metalcatalyzedcrosscouplingreactionsonazaindolesynthesisandfunctionalization
AT marquesmmanuelb metalcatalyzedcrosscouplingreactionsonazaindolesynthesisandfunctionalization

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