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Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation

A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify the cytotoxicity of misfolded proteins. A complemen...

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Detalles Bibliográficos
Autores principales:	Peters, Theodore W., Nelson, Christopher S., Gerencser, Akos A., Dumas, Kathleen J., Tavshanjian, Brandon, Chang, Kyu Chul, Lithgow, Gordon J., Hughes, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2018
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222566/ https://www.ncbi.nlm.nih.gov/pubmed/30194090 http://dx.doi.org/10.1534/g3.118.200289

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