Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical m...

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Autores principales: Lam, Sio-Hong, Chen, Po-Hsun, Hung, Hsin-Yi, Hwang, Tsong-Long, Chiang, Chih-Chao, Thang, Tran Dinh, Kuo, Ping-Chung, Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222598/
https://www.ncbi.nlm.nih.gov/pubmed/30301176
http://dx.doi.org/10.3390/molecules23102541
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author Lam, Sio-Hong
Chen, Po-Hsun
Hung, Hsin-Yi
Hwang, Tsong-Long
Chiang, Chih-Chao
Thang, Tran Dinh
Kuo, Ping-Chung
Wu, Tian-Shung
author_facet Lam, Sio-Hong
Chen, Po-Hsun
Hung, Hsin-Yi
Hwang, Tsong-Long
Chiang, Chih-Chao
Thang, Tran Dinh
Kuo, Ping-Chung
Wu, Tian-Shung
author_sort Lam, Sio-Hong
collection PubMed
description Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.
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spelling pubmed-62225982018-11-13 Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity Lam, Sio-Hong Chen, Po-Hsun Hung, Hsin-Yi Hwang, Tsong-Long Chiang, Chih-Chao Thang, Tran Dinh Kuo, Ping-Chung Wu, Tian-Shung Molecules Article Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release. MDPI 2018-10-05 /pmc/articles/PMC6222598/ /pubmed/30301176 http://dx.doi.org/10.3390/molecules23102541 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lam, Sio-Hong
Chen, Po-Hsun
Hung, Hsin-Yi
Hwang, Tsong-Long
Chiang, Chih-Chao
Thang, Tran Dinh
Kuo, Ping-Chung
Wu, Tian-Shung
Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity
title Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity
title_full Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity
title_fullStr Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity
title_full_unstemmed Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity
title_short Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity
title_sort chemical constituents from the stems of tinospora sinensis and their bioactivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222598/
https://www.ncbi.nlm.nih.gov/pubmed/30301176
http://dx.doi.org/10.3390/molecules23102541
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