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Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents
A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives (8–11)a–g was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7a–g with hydrazine hydrate and derivatives. Chalcones 7a–g were obtained by Claisen-Schmidt condensation...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222643/ https://www.ncbi.nlm.nih.gov/pubmed/30082588 http://dx.doi.org/10.3390/molecules23081956 |
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author | Moreno, Leydi M. Quiroga, Jairo Abonia, Rodrigo Ramírez-Prada, Jonathan Insuasty, Braulio |
author_facet | Moreno, Leydi M. Quiroga, Jairo Abonia, Rodrigo Ramírez-Prada, Jonathan Insuasty, Braulio |
author_sort | Moreno, Leydi M. |
collection | PubMed |
description | A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives (8–11)a–g was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7a–g with hydrazine hydrate and derivatives. Chalcones 7a–g were obtained by Claisen-Schmidt condensation between aromatic aldehydes and triazinic derivative 5, which was synthesized in high yield by a microwave-assisted reaction. Seventeen of the synthesized compounds were selected and tested by the US National Cancer Institute (NCI) for their anticancer activity against 58 different human tumor cell lines. Compounds 7g and 10d,e,g showed important GI(50) values ranging from 0.569 to 16.6 µM and LC(50) values ranging from 5.15 to >100 µM. |
format | Online Article Text |
id | pubmed-6222643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62226432018-11-13 Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents Moreno, Leydi M. Quiroga, Jairo Abonia, Rodrigo Ramírez-Prada, Jonathan Insuasty, Braulio Molecules Article A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives (8–11)a–g was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7a–g with hydrazine hydrate and derivatives. Chalcones 7a–g were obtained by Claisen-Schmidt condensation between aromatic aldehydes and triazinic derivative 5, which was synthesized in high yield by a microwave-assisted reaction. Seventeen of the synthesized compounds were selected and tested by the US National Cancer Institute (NCI) for their anticancer activity against 58 different human tumor cell lines. Compounds 7g and 10d,e,g showed important GI(50) values ranging from 0.569 to 16.6 µM and LC(50) values ranging from 5.15 to >100 µM. MDPI 2018-08-06 /pmc/articles/PMC6222643/ /pubmed/30082588 http://dx.doi.org/10.3390/molecules23081956 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moreno, Leydi M. Quiroga, Jairo Abonia, Rodrigo Ramírez-Prada, Jonathan Insuasty, Braulio Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents |
title | Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents |
title_full | Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents |
title_fullStr | Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents |
title_full_unstemmed | Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents |
title_short | Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents |
title_sort | synthesis of new 1,3,5-triazine-based 2-pyrazolines as potential anticancer agents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222643/ https://www.ncbi.nlm.nih.gov/pubmed/30082588 http://dx.doi.org/10.3390/molecules23081956 |
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