Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea

4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRE...

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Detalles Bibliográficos
Autores principales: Sandargo, Birthe, Thongbai, Benjarong, Praditya, Dimas, Steinmann, Eike, Stadler, Marc, Surup, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222660/
https://www.ncbi.nlm.nih.gov/pubmed/30347707
http://dx.doi.org/10.3390/molecules23102697
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author Sandargo, Birthe
Thongbai, Benjarong
Praditya, Dimas
Steinmann, Eike
Stadler, Marc
Surup, Frank
author_facet Sandargo, Birthe
Thongbai, Benjarong
Praditya, Dimas
Steinmann, Eike
Stadler, Marc
Surup, Frank
author_sort Sandargo, Birthe
collection PubMed
description 4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.
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spelling pubmed-62226602018-11-13 Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea Sandargo, Birthe Thongbai, Benjarong Praditya, Dimas Steinmann, Eike Stadler, Marc Surup, Frank Molecules Article 4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells. MDPI 2018-10-19 /pmc/articles/PMC6222660/ /pubmed/30347707 http://dx.doi.org/10.3390/molecules23102697 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sandargo, Birthe
Thongbai, Benjarong
Praditya, Dimas
Steinmann, Eike
Stadler, Marc
Surup, Frank
Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
title Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
title_full Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
title_fullStr Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
title_full_unstemmed Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
title_short Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
title_sort antiviral 4-hydroxypleurogrisein and antimicrobial pleurotin derivatives from cultures of the nematophagous basidiomycete hohenbuehelia grisea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222660/
https://www.ncbi.nlm.nih.gov/pubmed/30347707
http://dx.doi.org/10.3390/molecules23102697
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