New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii

Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirme...

Descripción completa

Detalles Bibliográficos
Autores principales: Ni, Lin, Zang, Ying-da, Yang, Jing-zhi, Li, Chuang-jun, Ma, Jie, Zhang, Dong-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222710/
https://www.ncbi.nlm.nih.gov/pubmed/30261626
http://dx.doi.org/10.3390/molecules23102467
Descripción
Sumario:Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.

Ejemplares similares