New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii

Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirme...

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Detalles Bibliográficos
Autores principales: Ni, Lin, Zang, Ying-da, Yang, Jing-zhi, Li, Chuang-jun, Ma, Jie, Zhang, Dong-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222710/
https://www.ncbi.nlm.nih.gov/pubmed/30261626
http://dx.doi.org/10.3390/molecules23102467
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author Ni, Lin
Zang, Ying-da
Yang, Jing-zhi
Li, Chuang-jun
Ma, Jie
Zhang, Dong-ming
author_facet Ni, Lin
Zang, Ying-da
Yang, Jing-zhi
Li, Chuang-jun
Ma, Jie
Zhang, Dong-ming
author_sort Ni, Lin
collection PubMed
description Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.
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spelling pubmed-62227102018-11-13 New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii Ni, Lin Zang, Ying-da Yang, Jing-zhi Li, Chuang-jun Ma, Jie Zhang, Dong-ming Molecules Article Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro. MDPI 2018-09-26 /pmc/articles/PMC6222710/ /pubmed/30261626 http://dx.doi.org/10.3390/molecules23102467 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ni, Lin
Zang, Ying-da
Yang, Jing-zhi
Li, Chuang-jun
Ma, Jie
Zhang, Dong-ming
New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
title New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
title_full New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
title_fullStr New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
title_full_unstemmed New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
title_short New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii
title_sort new 18(4→3)-abeo-abietanoids from tripterygium wilfordii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222710/
https://www.ncbi.nlm.nih.gov/pubmed/30261626
http://dx.doi.org/10.3390/molecules23102467
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