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Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos

Wolfiporia cocos is a fungus containing triterpenoids and is widely used as an herbal medicine. However, it is unknown whether its main triterpenoid contents differ in different tissues. In this study, we identified dehydrotumulosic acid, polyporenic acid C, pachymic acid, dehydrotrametenolic acid,...

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Autores principales: Fu, Ming, Wang, Li, Wang, Xianyou, Deng, Boxia, Hu, Xing, Zou, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222723/
https://www.ncbi.nlm.nih.gov/pubmed/30042340
http://dx.doi.org/10.3390/molecules23081839
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author Fu, Ming
Wang, Li
Wang, Xianyou
Deng, Boxia
Hu, Xing
Zou, Juan
author_facet Fu, Ming
Wang, Li
Wang, Xianyou
Deng, Boxia
Hu, Xing
Zou, Juan
author_sort Fu, Ming
collection PubMed
description Wolfiporia cocos is a fungus containing triterpenoids and is widely used as an herbal medicine. However, it is unknown whether its main triterpenoid contents differ in different tissues. In this study, we identified dehydrotumulosic acid, polyporenic acid C, pachymic acid, dehydrotrametenolic acid, and dehydroeburicoic acid as the five main triterpenoids in W. cocos. We also systematically profiled the contents and distribution of these main triterpenoids in different tissues of W. cocos. High contents of all five triterpenoids were found in the surface layer of W. cocos. Intriguingly, we noted that the highest contents of the five triterpenoids were found in the surface layer of the sclerotium grown under pollution-controlled cultivation; the second-highest contents were found in the surface layer of the natural sclerotium. These results indicate that environmentally friendly cultivation of the sclerotium of W. cocos is a practical way to increase the productivity of W. cocos. In addition, our findings suggest that the triterpenoids may contribute to the pharmacological activity of W. cocos, and the surface layer of sclerotium in W. cocos might be a promising raw material for applications in health care and the development of functional medical products.
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spelling pubmed-62227232018-11-13 Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos Fu, Ming Wang, Li Wang, Xianyou Deng, Boxia Hu, Xing Zou, Juan Molecules Article Wolfiporia cocos is a fungus containing triterpenoids and is widely used as an herbal medicine. However, it is unknown whether its main triterpenoid contents differ in different tissues. In this study, we identified dehydrotumulosic acid, polyporenic acid C, pachymic acid, dehydrotrametenolic acid, and dehydroeburicoic acid as the five main triterpenoids in W. cocos. We also systematically profiled the contents and distribution of these main triterpenoids in different tissues of W. cocos. High contents of all five triterpenoids were found in the surface layer of W. cocos. Intriguingly, we noted that the highest contents of the five triterpenoids were found in the surface layer of the sclerotium grown under pollution-controlled cultivation; the second-highest contents were found in the surface layer of the natural sclerotium. These results indicate that environmentally friendly cultivation of the sclerotium of W. cocos is a practical way to increase the productivity of W. cocos. In addition, our findings suggest that the triterpenoids may contribute to the pharmacological activity of W. cocos, and the surface layer of sclerotium in W. cocos might be a promising raw material for applications in health care and the development of functional medical products. MDPI 2018-07-24 /pmc/articles/PMC6222723/ /pubmed/30042340 http://dx.doi.org/10.3390/molecules23081839 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Ming
Wang, Li
Wang, Xianyou
Deng, Boxia
Hu, Xing
Zou, Juan
Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos
title Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos
title_full Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos
title_fullStr Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos
title_full_unstemmed Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos
title_short Determination of the Five Main Terpenoids in Different Tissues of Wolfiporia cocos
title_sort determination of the five main terpenoids in different tissues of wolfiporia cocos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222723/
https://www.ncbi.nlm.nih.gov/pubmed/30042340
http://dx.doi.org/10.3390/molecules23081839
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