Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media

A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K(2)CO(3), EtOH/H(2)O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The m...

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Detalles Bibliográficos
Autores principales: Chen, Qianqian, Jiang, Panli, Guo, Mengping, Yang, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222736/
https://www.ncbi.nlm.nih.gov/pubmed/30257438
http://dx.doi.org/10.3390/molecules23102450
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author Chen, Qianqian
Jiang, Panli
Guo, Mengping
Yang, Jianxin
author_facet Chen, Qianqian
Jiang, Panli
Guo, Mengping
Yang, Jianxin
author_sort Chen, Qianqian
collection PubMed
description A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K(2)CO(3), EtOH/H(2)O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The methodology allows the facile production of heterobiaryl compounds, a unique architectural motif that is ubiquitous in medicinal chemistry.
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spelling pubmed-62227362018-11-13 Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media Chen, Qianqian Jiang, Panli Guo, Mengping Yang, Jianxin Molecules Communication A series of novel benzofuran derivatives containing biaryl moiety were designed and synthesized by the Suzuki cross-coupling reactions. The reactions, performed in the presence of K(2)CO(3), EtOH/H(2)O and Pd(II) complex as catalyst, gave the corresponding products in good to excellent yields. The methodology allows the facile production of heterobiaryl compounds, a unique architectural motif that is ubiquitous in medicinal chemistry. MDPI 2018-09-25 /pmc/articles/PMC6222736/ /pubmed/30257438 http://dx.doi.org/10.3390/molecules23102450 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Chen, Qianqian
Jiang, Panli
Guo, Mengping
Yang, Jianxin
Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media
title Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media
title_full Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media
title_fullStr Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media
title_full_unstemmed Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media
title_short Synthesis of New 2-Arylbenzo[b]furan Derivatives via Palladium-Catalyzed Suzuki Cross-Coupling Reactions in Aqueous Media
title_sort synthesis of new 2-arylbenzo[b]furan derivatives via palladium-catalyzed suzuki cross-coupling reactions in aqueous media
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222736/
https://www.ncbi.nlm.nih.gov/pubmed/30257438
http://dx.doi.org/10.3390/molecules23102450
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AT guomengping synthesisofnew2arylbenzobfuranderivativesviapalladiumcatalyzedsuzukicrosscouplingreactionsinaqueousmedia
AT yangjianxin synthesisofnew2arylbenzobfuranderivativesviapalladiumcatalyzedsuzukicrosscouplingreactionsinaqueousmedia

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