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A Dynamic Overview of Antimicrobial Peptides and Their Complexes
In this narrative review, we comprehensively review the available information about the recognition, structure, and dynamics of antimicrobial peptides (AMPs). Their complex behaviors occur across a wide range of time scales and have been challenging to portray. Recent advances in nuclear magnetic re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222744/ https://www.ncbi.nlm.nih.gov/pubmed/30111717 http://dx.doi.org/10.3390/molecules23082040 |
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author | de Paula, Viviane Silva Valente, Ana Paula |
author_facet | de Paula, Viviane Silva Valente, Ana Paula |
author_sort | de Paula, Viviane Silva |
collection | PubMed |
description | In this narrative review, we comprehensively review the available information about the recognition, structure, and dynamics of antimicrobial peptides (AMPs). Their complex behaviors occur across a wide range of time scales and have been challenging to portray. Recent advances in nuclear magnetic resonance and molecular dynamics simulations have revealed the importance of the molecular plasticity of AMPs and their abilities to recognize targets. We also highlight experimental data obtained using nuclear magnetic resonance methodologies, showing that conformational selection is a major mechanism of target interaction in AMP families. |
format | Online Article Text |
id | pubmed-6222744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62227442018-11-13 A Dynamic Overview of Antimicrobial Peptides and Their Complexes de Paula, Viviane Silva Valente, Ana Paula Molecules Review In this narrative review, we comprehensively review the available information about the recognition, structure, and dynamics of antimicrobial peptides (AMPs). Their complex behaviors occur across a wide range of time scales and have been challenging to portray. Recent advances in nuclear magnetic resonance and molecular dynamics simulations have revealed the importance of the molecular plasticity of AMPs and their abilities to recognize targets. We also highlight experimental data obtained using nuclear magnetic resonance methodologies, showing that conformational selection is a major mechanism of target interaction in AMP families. MDPI 2018-08-15 /pmc/articles/PMC6222744/ /pubmed/30111717 http://dx.doi.org/10.3390/molecules23082040 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Paula, Viviane Silva Valente, Ana Paula A Dynamic Overview of Antimicrobial Peptides and Their Complexes |
title | A Dynamic Overview of Antimicrobial Peptides and Their Complexes |
title_full | A Dynamic Overview of Antimicrobial Peptides and Their Complexes |
title_fullStr | A Dynamic Overview of Antimicrobial Peptides and Their Complexes |
title_full_unstemmed | A Dynamic Overview of Antimicrobial Peptides and Their Complexes |
title_short | A Dynamic Overview of Antimicrobial Peptides and Their Complexes |
title_sort | dynamic overview of antimicrobial peptides and their complexes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222744/ https://www.ncbi.nlm.nih.gov/pubmed/30111717 http://dx.doi.org/10.3390/molecules23082040 |
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