Design, Synthesis, and Antiproliferative Evaluation of Novel Coumarin/2-Cyanoacryloyl Hybrids as Apoptosis Inducing Agents by Activation of Caspase-Dependent Pathway

A series of novel coumarin/2-cyanoacryloyl hybrids were prepared and evaluated for their in vitro anticancer activity. Among them, two analogs 5p and 5q showed promising antiproliferative activity against a panel of cancer cell lines, including A549, H157, HepG2, MCF7, MG63, and U2OS. Particularly,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yu-Ying, Zhang, Qian-Qian, Song, Jia-Li, Zhang, Liang, Jiang, Cheng-Shi, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222758/
https://www.ncbi.nlm.nih.gov/pubmed/30087276
http://dx.doi.org/10.3390/molecules23081972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222758/
https://www.ncbi.nlm.nih.gov/pubmed/30087276
http://dx.doi.org/10.3390/molecules23081972

Ejemplares similares