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Design, Synthesis, and Antiproliferative Evaluation of Novel Coumarin/2-Cyanoacryloyl Hybrids as Apoptosis Inducing Agents by Activation of Caspase-Dependent Pathway

A series of novel coumarin/2-cyanoacryloyl hybrids were prepared and evaluated for their in vitro anticancer activity. Among them, two analogs 5p and 5q showed promising antiproliferative activity against a panel of cancer cell lines, including A549, H157, HepG2, MCF7, MG63, and U2OS. Particularly,...

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Detalles Bibliográficos
Autores principales:	Zhang, Yu-Ying, Zhang, Qian-Qian, Song, Jia-Li, Zhang, Liang, Jiang, Cheng-Shi, Zhang, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222758/ https://www.ncbi.nlm.nih.gov/pubmed/30087276 http://dx.doi.org/10.3390/molecules23081972

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