Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especi...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Hongjing, Geng, Yanling, Wang, Xueyong, Song, Xiangyun, Wang, Xiao, Yu, Jinqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222759/
https://www.ncbi.nlm.nih.gov/pubmed/30304808
http://dx.doi.org/10.3390/molecules23102577
_version_ 1783369281780580352
author Dong, Hongjing
Geng, Yanling
Wang, Xueyong
Song, Xiangyun
Wang, Xiao
Yu, Jinqian
author_facet Dong, Hongjing
Geng, Yanling
Wang, Xueyong
Song, Xiangyun
Wang, Xiao
Yu, Jinqian
author_sort Dong, Hongjing
collection PubMed
description One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC(50) values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.
format Online
Article
Text
id pubmed-6222759
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62227592018-11-13 Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities Dong, Hongjing Geng, Yanling Wang, Xueyong Song, Xiangyun Wang, Xiao Yu, Jinqian Molecules Article One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC(50) values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively. MDPI 2018-10-09 /pmc/articles/PMC6222759/ /pubmed/30304808 http://dx.doi.org/10.3390/molecules23102577 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dong, Hongjing
Geng, Yanling
Wang, Xueyong
Song, Xiangyun
Wang, Xiao
Yu, Jinqian
Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_full Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_fullStr Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_full_unstemmed Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_short Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_sort chemical constituents from scindapsus officinalis (roxb.) schott. and their anti–inflammatory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222759/
https://www.ncbi.nlm.nih.gov/pubmed/30304808
http://dx.doi.org/10.3390/molecules23102577
work_keys_str_mv AT donghongjing chemicalconstituentsfromscindapsusofficinalisroxbschottandtheirantiinflammatoryactivities
AT gengyanling chemicalconstituentsfromscindapsusofficinalisroxbschottandtheirantiinflammatoryactivities
AT wangxueyong chemicalconstituentsfromscindapsusofficinalisroxbschottandtheirantiinflammatoryactivities
AT songxiangyun chemicalconstituentsfromscindapsusofficinalisroxbschottandtheirantiinflammatoryactivities
AT wangxiao chemicalconstituentsfromscindapsusofficinalisroxbschottandtheirantiinflammatoryactivities
AT yujinqian chemicalconstituentsfromscindapsusofficinalisroxbschottandtheirantiinflammatoryactivities

Ejemplares similares