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A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples

Pharmacokinetic studies are crucial for elucidating the effective constituents and formula compatibility of traditional Chinese medicines (TCMs). However, studies have usually been limited to single dosages and detection of systemic blood concentrations. To obtain comprehensive pharmacokinetic infor...

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Autores principales: Li, Qiao, Yang, Yan, Zhou, Ting, Wang, Rui, Li, Na, Zheng, Min, Li, Yuan-Yuan, Zhang, Ji-Quan, Wu, Fei, Yang, Bai-Can, Ma, Yue-Ming, Ma, Bing-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222803/
https://www.ncbi.nlm.nih.gov/pubmed/30111723
http://dx.doi.org/10.3390/molecules23082042
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author Li, Qiao
Yang, Yan
Zhou, Ting
Wang, Rui
Li, Na
Zheng, Min
Li, Yuan-Yuan
Zhang, Ji-Quan
Wu, Fei
Yang, Bai-Can
Ma, Yue-Ming
Ma, Bing-Liang
author_facet Li, Qiao
Yang, Yan
Zhou, Ting
Wang, Rui
Li, Na
Zheng, Min
Li, Yuan-Yuan
Zhang, Ji-Quan
Wu, Fei
Yang, Bai-Can
Ma, Yue-Ming
Ma, Bing-Liang
author_sort Li, Qiao
collection PubMed
description Pharmacokinetic studies are crucial for elucidating the effective constituents and formula compatibility of traditional Chinese medicines (TCMs). However, studies have usually been limited to single dosages and detection of systemic blood concentrations. To obtain comprehensive pharmacokinetic information, here we propose a multi-dosage and multi-sampling (blood from portal vein or systemic circulation, and liver) strategy to comparatively study the pharmacokinetics of multi-form TCMs, i.e., pure constituents, TCMs, or TCM formula extracts. Based on this strategy, we studied the pharmacokinetics of pure berberine, berberine in Coptidis Rhizoma (CRE), and berberine in Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma extracts (CR-GRE). After simple calculation and comparison of the obtained area under the curve (AUC) values, the results revealed the drastically different pharmacokinetic properties of pure berberine compared to CRE and CR-GRE. The results contribute to explaining the pharmacological loss of berberine activity after purification and the compatibility of the CR-GR drug pair. The results also innovatively showed that it was intestinal absorption that differentiated the pharmacokinetics of CRE and pure berberine, and CRE and CR-GRE. In conclusion, we propose a composite strategy to comparatively study the pharmacokinetics of TCMs, which could provide sufficient information to obtain a comprehensive view, before follow-up mechanism-of-action studies.
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spelling pubmed-62228032018-11-13 A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples Li, Qiao Yang, Yan Zhou, Ting Wang, Rui Li, Na Zheng, Min Li, Yuan-Yuan Zhang, Ji-Quan Wu, Fei Yang, Bai-Can Ma, Yue-Ming Ma, Bing-Liang Molecules Article Pharmacokinetic studies are crucial for elucidating the effective constituents and formula compatibility of traditional Chinese medicines (TCMs). However, studies have usually been limited to single dosages and detection of systemic blood concentrations. To obtain comprehensive pharmacokinetic information, here we propose a multi-dosage and multi-sampling (blood from portal vein or systemic circulation, and liver) strategy to comparatively study the pharmacokinetics of multi-form TCMs, i.e., pure constituents, TCMs, or TCM formula extracts. Based on this strategy, we studied the pharmacokinetics of pure berberine, berberine in Coptidis Rhizoma (CRE), and berberine in Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma extracts (CR-GRE). After simple calculation and comparison of the obtained area under the curve (AUC) values, the results revealed the drastically different pharmacokinetic properties of pure berberine compared to CRE and CR-GRE. The results contribute to explaining the pharmacological loss of berberine activity after purification and the compatibility of the CR-GR drug pair. The results also innovatively showed that it was intestinal absorption that differentiated the pharmacokinetics of CRE and pure berberine, and CRE and CR-GRE. In conclusion, we propose a composite strategy to comparatively study the pharmacokinetics of TCMs, which could provide sufficient information to obtain a comprehensive view, before follow-up mechanism-of-action studies. MDPI 2018-08-15 /pmc/articles/PMC6222803/ /pubmed/30111723 http://dx.doi.org/10.3390/molecules23082042 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Qiao
Yang, Yan
Zhou, Ting
Wang, Rui
Li, Na
Zheng, Min
Li, Yuan-Yuan
Zhang, Ji-Quan
Wu, Fei
Yang, Bai-Can
Ma, Yue-Ming
Ma, Bing-Liang
A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples
title A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples
title_full A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples
title_fullStr A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples
title_full_unstemmed A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples
title_short A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples
title_sort compositive strategy to study the pharmacokinetics of tcms: taking coptidis rhizoma, and coptidis rhizoma-glycyrrhizae radix et rhizoma as examples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222803/
https://www.ncbi.nlm.nih.gov/pubmed/30111723
http://dx.doi.org/10.3390/molecules23082042
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