A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos

A previously undescribed naphthalenone derivative, sohiracillinone (1), and a novel 4,5-seco-lanostane triterpenoid, 11β-ethoxydaedaleanic acid A (2) were isolated with two new lanostane triterpenoids, ceanphytamic acids A (3) and B (4), from the EtOH extract of Poria cocos along with 17 known compo...

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Autores principales: Chen, Ting, Hua, La, Chou, Guixin, Mao, Xudong, Zou, Xianliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222825/
https://www.ncbi.nlm.nih.gov/pubmed/30274339
http://dx.doi.org/10.3390/molecules23102508
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author Chen, Ting
Hua, La
Chou, Guixin
Mao, Xudong
Zou, Xianliang
author_facet Chen, Ting
Hua, La
Chou, Guixin
Mao, Xudong
Zou, Xianliang
author_sort Chen, Ting
collection PubMed
description A previously undescribed naphthalenone derivative, sohiracillinone (1), and a novel 4,5-seco-lanostane triterpenoid, 11β-ethoxydaedaleanic acid A (2) were isolated with two new lanostane triterpenoids, ceanphytamic acids A (3) and B (4), from the EtOH extract of Poria cocos along with 17 known compounds 5–21. The absolute configuration of sohiracillinone (1) was unambiguously identified by NMR and electronic circular dichroism (ECD) data. The structures of other new compounds were elucidated on the basis of NMR and mass spectroscopy (MS), and the cytotoxic activities of all the isolated components were evaluated.
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spelling pubmed-62228252018-11-13 A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos Chen, Ting Hua, La Chou, Guixin Mao, Xudong Zou, Xianliang Molecules Article A previously undescribed naphthalenone derivative, sohiracillinone (1), and a novel 4,5-seco-lanostane triterpenoid, 11β-ethoxydaedaleanic acid A (2) were isolated with two new lanostane triterpenoids, ceanphytamic acids A (3) and B (4), from the EtOH extract of Poria cocos along with 17 known compounds 5–21. The absolute configuration of sohiracillinone (1) was unambiguously identified by NMR and electronic circular dichroism (ECD) data. The structures of other new compounds were elucidated on the basis of NMR and mass spectroscopy (MS), and the cytotoxic activities of all the isolated components were evaluated. MDPI 2018-09-30 /pmc/articles/PMC6222825/ /pubmed/30274339 http://dx.doi.org/10.3390/molecules23102508 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Ting
Hua, La
Chou, Guixin
Mao, Xudong
Zou, Xianliang
A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos
title A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos
title_full A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos
title_fullStr A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos
title_full_unstemmed A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos
title_short A Unique Naphthone Derivative and a Rare 4,5-seco-Lanostane Triterpenoid from Poria cocos
title_sort unique naphthone derivative and a rare 4,5-seco-lanostane triterpenoid from poria cocos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222825/
https://www.ncbi.nlm.nih.gov/pubmed/30274339
http://dx.doi.org/10.3390/molecules23102508
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