Design of a New α-1-C-Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for β-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation

Some point mutations in β-glucocerebrosidase cause either improper folding or instability of this protein, resulting in Gaucher disease. Pharmacological chaperones bind to the mutant enzyme and stabilize this enzyme; thus, pharmacological chaperone therapy was proposed as a potential treatment for G...

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Detalles Bibliográficos
Autores principales: Nakagome, Izumi, Kato, Atsushi, Yamaotsu, Noriyuki, Yoshida, Tomoki, Ozawa, Shin-ichiro, Adachi, Isao, Hirono, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222826/
https://www.ncbi.nlm.nih.gov/pubmed/30340368
http://dx.doi.org/10.3390/molecules23102683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222826/
https://www.ncbi.nlm.nih.gov/pubmed/30340368
http://dx.doi.org/10.3390/molecules23102683

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