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Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial

Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on physiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and saliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers were recruited to...

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Autores principales: Varoni, Elena M., Paroni, Rita, Antognetti, Jacopo, Lodi, Giovanni, Sardella, Andrea, Carrassi, Antonio, Iriti, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222864/
https://www.ncbi.nlm.nih.gov/pubmed/30261680
http://dx.doi.org/10.3390/molecules23102474
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author Varoni, Elena M.
Paroni, Rita
Antognetti, Jacopo
Lodi, Giovanni
Sardella, Andrea
Carrassi, Antonio
Iriti, Marcello
author_facet Varoni, Elena M.
Paroni, Rita
Antognetti, Jacopo
Lodi, Giovanni
Sardella, Andrea
Carrassi, Antonio
Iriti, Marcello
author_sort Varoni, Elena M.
collection PubMed
description Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on physiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and saliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers were recruited to receive 125 mL of red wine naturally lacking of MLT (placebo, PLC), or the same wine enriched with MLT (MLT+). A physiological steady decline of serum MLT was observed from baseline up to 90 min, for both wines. After PLC intake, the decrease was significantly faster than the one occurring after MLT+ wine, which thus delayed the drop down of serum MLT with a plateau at 30–60 min. Salivary MLT levels slightly peaked at 45 min after MLT+ wine intake, without statistical significance. Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of the indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the hormone into the bloodstream.
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spelling pubmed-62228642018-11-13 Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial Varoni, Elena M. Paroni, Rita Antognetti, Jacopo Lodi, Giovanni Sardella, Andrea Carrassi, Antonio Iriti, Marcello Molecules Article Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on physiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and saliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers were recruited to receive 125 mL of red wine naturally lacking of MLT (placebo, PLC), or the same wine enriched with MLT (MLT+). A physiological steady decline of serum MLT was observed from baseline up to 90 min, for both wines. After PLC intake, the decrease was significantly faster than the one occurring after MLT+ wine, which thus delayed the drop down of serum MLT with a plateau at 30–60 min. Salivary MLT levels slightly peaked at 45 min after MLT+ wine intake, without statistical significance. Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of the indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the hormone into the bloodstream. MDPI 2018-09-27 /pmc/articles/PMC6222864/ /pubmed/30261680 http://dx.doi.org/10.3390/molecules23102474 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Varoni, Elena M.
Paroni, Rita
Antognetti, Jacopo
Lodi, Giovanni
Sardella, Andrea
Carrassi, Antonio
Iriti, Marcello
Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
title Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
title_full Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
title_fullStr Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
title_full_unstemmed Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
title_short Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
title_sort effect of red wine intake on serum and salivary melatonin levels: a randomized, placebo-controlled clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222864/
https://www.ncbi.nlm.nih.gov/pubmed/30261680
http://dx.doi.org/10.3390/molecules23102474
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