Cargando…
Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial
Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on physiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and saliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers were recruited to...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222864/ https://www.ncbi.nlm.nih.gov/pubmed/30261680 http://dx.doi.org/10.3390/molecules23102474 |
_version_ | 1783369306653851648 |
---|---|
author | Varoni, Elena M. Paroni, Rita Antognetti, Jacopo Lodi, Giovanni Sardella, Andrea Carrassi, Antonio Iriti, Marcello |
author_facet | Varoni, Elena M. Paroni, Rita Antognetti, Jacopo Lodi, Giovanni Sardella, Andrea Carrassi, Antonio Iriti, Marcello |
author_sort | Varoni, Elena M. |
collection | PubMed |
description | Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on physiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and saliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers were recruited to receive 125 mL of red wine naturally lacking of MLT (placebo, PLC), or the same wine enriched with MLT (MLT+). A physiological steady decline of serum MLT was observed from baseline up to 90 min, for both wines. After PLC intake, the decrease was significantly faster than the one occurring after MLT+ wine, which thus delayed the drop down of serum MLT with a plateau at 30–60 min. Salivary MLT levels slightly peaked at 45 min after MLT+ wine intake, without statistical significance. Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of the indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the hormone into the bloodstream. |
format | Online Article Text |
id | pubmed-6222864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62228642018-11-13 Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial Varoni, Elena M. Paroni, Rita Antognetti, Jacopo Lodi, Giovanni Sardella, Andrea Carrassi, Antonio Iriti, Marcello Molecules Article Melatonin (MLT) is a recently discovered phytochemical in wine, but its influence on physiological MLT levels is still unknown. This study aimed at evaluating variations, in serum and saliva, of MLT concentrations after the intake of MLT-enriched red wine. Twelve healthy volunteers were recruited to receive 125 mL of red wine naturally lacking of MLT (placebo, PLC), or the same wine enriched with MLT (MLT+). A physiological steady decline of serum MLT was observed from baseline up to 90 min, for both wines. After PLC intake, the decrease was significantly faster than the one occurring after MLT+ wine, which thus delayed the drop down of serum MLT with a plateau at 30–60 min. Salivary MLT levels slightly peaked at 45 min after MLT+ wine intake, without statistical significance. Therefore, the intake of a glass of MLT-enriched red wine changed serum levels of the indoleamine, supporting the role of wine MLT in counteracting the physiological decline of the hormone into the bloodstream. MDPI 2018-09-27 /pmc/articles/PMC6222864/ /pubmed/30261680 http://dx.doi.org/10.3390/molecules23102474 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Varoni, Elena M. Paroni, Rita Antognetti, Jacopo Lodi, Giovanni Sardella, Andrea Carrassi, Antonio Iriti, Marcello Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial |
title | Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial |
title_full | Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial |
title_fullStr | Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial |
title_full_unstemmed | Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial |
title_short | Effect of Red Wine Intake on Serum and Salivary Melatonin Levels: A Randomized, Placebo-Controlled Clinical Trial |
title_sort | effect of red wine intake on serum and salivary melatonin levels: a randomized, placebo-controlled clinical trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222864/ https://www.ncbi.nlm.nih.gov/pubmed/30261680 http://dx.doi.org/10.3390/molecules23102474 |
work_keys_str_mv | AT varonielenam effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial AT paronirita effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial AT antognettijacopo effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial AT lodigiovanni effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial AT sardellaandrea effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial AT carrassiantonio effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial AT iritimarcello effectofredwineintakeonserumandsalivarymelatoninlevelsarandomizedplacebocontrolledclinicaltrial |