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Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis

The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been known as a remedy for chronic dysentery. The hydrodistilled essential oil of the aerial parts of...

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Autores principales: Tomczykowa, Monika, Wróblewska, Magdalena, Winnicka, Katarzyna, Wieczorek, Piotr, Majewski, Piotr, Celińska-Janowicz, Katarzyna, Sawczuk, Róża, Miltyk, Wojciech, Tryniszewska, Elżbieta, Tomczyk, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222870/
https://www.ncbi.nlm.nih.gov/pubmed/30275354
http://dx.doi.org/10.3390/molecules23102517
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author Tomczykowa, Monika
Wróblewska, Magdalena
Winnicka, Katarzyna
Wieczorek, Piotr
Majewski, Piotr
Celińska-Janowicz, Katarzyna
Sawczuk, Róża
Miltyk, Wojciech
Tryniszewska, Elżbieta
Tomczyk, Michał
author_facet Tomczykowa, Monika
Wróblewska, Magdalena
Winnicka, Katarzyna
Wieczorek, Piotr
Majewski, Piotr
Celińska-Janowicz, Katarzyna
Sawczuk, Róża
Miltyk, Wojciech
Tryniszewska, Elżbieta
Tomczyk, Michał
author_sort Tomczykowa, Monika
collection PubMed
description The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been known as a remedy for chronic dysentery. The hydrodistilled essential oil of the aerial parts of the Polish B. tripartita was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. To exclude any potential toxic effects of the oil on human dermal fibroblasts, the MTT test (methyl thiazolyl tetrazolium) and COMET assay (single-cell gel electrophoresis) were performed. Novel gel formulations as topical carriers for essential oil obtained from B. tripartita were developed and characterized. The bioadhesive properties of the designed preparations in the ex vivo model using the skin of hairless mice were also evaluated. The therapeutic efficacy of the topical formulations is influenced by active phytoconstituents and vehicle characteristics. The antifungal properties of the essential oil of B. tripartita were also tested against Candida species, and this oil appears to be a promising topical anticandidal agent.
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spelling pubmed-62228702018-11-13 Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis Tomczykowa, Monika Wróblewska, Magdalena Winnicka, Katarzyna Wieczorek, Piotr Majewski, Piotr Celińska-Janowicz, Katarzyna Sawczuk, Róża Miltyk, Wojciech Tryniszewska, Elżbieta Tomczyk, Michał Molecules Article The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been known as a remedy for chronic dysentery. The hydrodistilled essential oil of the aerial parts of the Polish B. tripartita was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. To exclude any potential toxic effects of the oil on human dermal fibroblasts, the MTT test (methyl thiazolyl tetrazolium) and COMET assay (single-cell gel electrophoresis) were performed. Novel gel formulations as topical carriers for essential oil obtained from B. tripartita were developed and characterized. The bioadhesive properties of the designed preparations in the ex vivo model using the skin of hairless mice were also evaluated. The therapeutic efficacy of the topical formulations is influenced by active phytoconstituents and vehicle characteristics. The antifungal properties of the essential oil of B. tripartita were also tested against Candida species, and this oil appears to be a promising topical anticandidal agent. MDPI 2018-10-01 /pmc/articles/PMC6222870/ /pubmed/30275354 http://dx.doi.org/10.3390/molecules23102517 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tomczykowa, Monika
Wróblewska, Magdalena
Winnicka, Katarzyna
Wieczorek, Piotr
Majewski, Piotr
Celińska-Janowicz, Katarzyna
Sawczuk, Róża
Miltyk, Wojciech
Tryniszewska, Elżbieta
Tomczyk, Michał
Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
title Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
title_full Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
title_fullStr Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
title_full_unstemmed Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
title_short Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
title_sort novel gel formulations as topical carriers for the essential oil of bidens tripartita for the treatment of candidiasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222870/
https://www.ncbi.nlm.nih.gov/pubmed/30275354
http://dx.doi.org/10.3390/molecules23102517
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