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Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis
The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been known as a remedy for chronic dysentery. The hydrodistilled essential oil of the aerial parts of...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222870/ https://www.ncbi.nlm.nih.gov/pubmed/30275354 http://dx.doi.org/10.3390/molecules23102517 |
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author | Tomczykowa, Monika Wróblewska, Magdalena Winnicka, Katarzyna Wieczorek, Piotr Majewski, Piotr Celińska-Janowicz, Katarzyna Sawczuk, Róża Miltyk, Wojciech Tryniszewska, Elżbieta Tomczyk, Michał |
author_facet | Tomczykowa, Monika Wróblewska, Magdalena Winnicka, Katarzyna Wieczorek, Piotr Majewski, Piotr Celińska-Janowicz, Katarzyna Sawczuk, Róża Miltyk, Wojciech Tryniszewska, Elżbieta Tomczyk, Michał |
author_sort | Tomczykowa, Monika |
collection | PubMed |
description | The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been known as a remedy for chronic dysentery. The hydrodistilled essential oil of the aerial parts of the Polish B. tripartita was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. To exclude any potential toxic effects of the oil on human dermal fibroblasts, the MTT test (methyl thiazolyl tetrazolium) and COMET assay (single-cell gel electrophoresis) were performed. Novel gel formulations as topical carriers for essential oil obtained from B. tripartita were developed and characterized. The bioadhesive properties of the designed preparations in the ex vivo model using the skin of hairless mice were also evaluated. The therapeutic efficacy of the topical formulations is influenced by active phytoconstituents and vehicle characteristics. The antifungal properties of the essential oil of B. tripartita were also tested against Candida species, and this oil appears to be a promising topical anticandidal agent. |
format | Online Article Text |
id | pubmed-6222870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62228702018-11-13 Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis Tomczykowa, Monika Wróblewska, Magdalena Winnicka, Katarzyna Wieczorek, Piotr Majewski, Piotr Celińska-Janowicz, Katarzyna Sawczuk, Róża Miltyk, Wojciech Tryniszewska, Elżbieta Tomczyk, Michał Molecules Article The genus Bidens L. (Asteraceae) refers to several species of plants used in traditional phytotherapeutic preparations. B. tripartita, also known as bur marigold, is the most familiar plant and has been known as a remedy for chronic dysentery. The hydrodistilled essential oil of the aerial parts of the Polish B. tripartita was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. To exclude any potential toxic effects of the oil on human dermal fibroblasts, the MTT test (methyl thiazolyl tetrazolium) and COMET assay (single-cell gel electrophoresis) were performed. Novel gel formulations as topical carriers for essential oil obtained from B. tripartita were developed and characterized. The bioadhesive properties of the designed preparations in the ex vivo model using the skin of hairless mice were also evaluated. The therapeutic efficacy of the topical formulations is influenced by active phytoconstituents and vehicle characteristics. The antifungal properties of the essential oil of B. tripartita were also tested against Candida species, and this oil appears to be a promising topical anticandidal agent. MDPI 2018-10-01 /pmc/articles/PMC6222870/ /pubmed/30275354 http://dx.doi.org/10.3390/molecules23102517 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tomczykowa, Monika Wróblewska, Magdalena Winnicka, Katarzyna Wieczorek, Piotr Majewski, Piotr Celińska-Janowicz, Katarzyna Sawczuk, Róża Miltyk, Wojciech Tryniszewska, Elżbieta Tomczyk, Michał Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis |
title | Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis |
title_full | Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis |
title_fullStr | Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis |
title_full_unstemmed | Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis |
title_short | Novel Gel Formulations as Topical Carriers for the Essential Oil of Bidens tripartita for the Treatment of Candidiasis |
title_sort | novel gel formulations as topical carriers for the essential oil of bidens tripartita for the treatment of candidiasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222870/ https://www.ncbi.nlm.nih.gov/pubmed/30275354 http://dx.doi.org/10.3390/molecules23102517 |
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