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Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib‐Induced Hypertension

BACKGROUND: The tyrosine kinase inhibitor sunitinib causes hypertension associated with reduced nitric oxide (NO) availability, elevated renal vascular resistance, and decreased fractional sodium excretion. We tested whether (1) nitrate supplementation mitigates sunitinib‐induced hypertension and NO...

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Detalles Bibliográficos
Autores principales:	Witte, Jeannine, Mühlbauer, Melanie, Braun, Diana, Steinbach, Antje, Golchert, Janine, Rettig, Rainer, Grisk, Olaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222942/ https://www.ncbi.nlm.nih.gov/pubmed/30371202 http://dx.doi.org/10.1161/JAHA.118.009557

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