Aging of mesenchymal stem cells: Implication in regenerative medicine

Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-ind...

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Detalles Bibliográficos
Autor principal: Yang, Yueh-Hsun Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222976/
https://www.ncbi.nlm.nih.gov/pubmed/30525083
http://dx.doi.org/10.1016/j.reth.2018.09.002
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author Yang, Yueh-Hsun Kevin
author_facet Yang, Yueh-Hsun Kevin
author_sort Yang, Yueh-Hsun Kevin
collection PubMed
description Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs.
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spelling pubmed-62229762018-12-06 Aging of mesenchymal stem cells: Implication in regenerative medicine Yang, Yueh-Hsun Kevin Regen Ther Commentary Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs. Japanese Society for Regenerative Medicine 2018-11-03 /pmc/articles/PMC6222976/ /pubmed/30525083 http://dx.doi.org/10.1016/j.reth.2018.09.002 Text en © 2018 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Yang, Yueh-Hsun Kevin
Aging of mesenchymal stem cells: Implication in regenerative medicine
title Aging of mesenchymal stem cells: Implication in regenerative medicine
title_full Aging of mesenchymal stem cells: Implication in regenerative medicine
title_fullStr Aging of mesenchymal stem cells: Implication in regenerative medicine
title_full_unstemmed Aging of mesenchymal stem cells: Implication in regenerative medicine
title_short Aging of mesenchymal stem cells: Implication in regenerative medicine
title_sort aging of mesenchymal stem cells: implication in regenerative medicine
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222976/
https://www.ncbi.nlm.nih.gov/pubmed/30525083
http://dx.doi.org/10.1016/j.reth.2018.09.002
work_keys_str_mv AT yangyuehhsunkevin agingofmesenchymalstemcellsimplicationinregenerativemedicine

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