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LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

BACKGROUND: The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and histone methylation and acetylation landscapes. We previousl...

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Detalles Bibliográficos
Autores principales:	Grigoryan, Ani, Guidi, Novella, Senger, Katharina, Liehr, Thomas, Soller, Karin, Marka, Gina, Vollmer, Angelika, Markaki, Yolanda, Leonhardt, Heinrich, Buske, Christian, Lipka, Daniel B., Plass, Christoph, Zheng, Yi, Mulaw, Medhanie A., Geiger, Hartmut, Florian, Maria Carolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223039/ https://www.ncbi.nlm.nih.gov/pubmed/30404662 http://dx.doi.org/10.1186/s13059-018-1557-3

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