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Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

BACKGROUND: The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neurons of adult mouse models for amyotrophic lateral sclerosis (ALS), yet the mole...

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Detalles Bibliográficos
Autores principales:	Lee, Yi-Chao, Huang, Wan-Chen, Lin, Jiann-Her, Kao, Tzu-Jen, Lin, Hui-Ching, Lee, Kuen-Haur, Lin, Hsin-Chuan, Shen, Che-Kun James, Chang, Wen-Chang, Huang, Chi-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223059/ https://www.ncbi.nlm.nih.gov/pubmed/30404641 http://dx.doi.org/10.1186/s12929-018-0479-4

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