Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer

BACKGROUND: The mutational processes underlying non-coding cancer mutations and their biological significance in tumor evolution are poorly understood. To get better insights into the biological mechanisms of mutational processes in breast cancer, we integrate whole-genome level somatic mutations fr...

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Detalles Bibliográficos
Autores principales: Yang, Jiekun, Wei, Xiaolong, Tufan, Turan, Kuscu, Cem, Unlu, Hayrunnisa, Farooq, Saadia, Demirtas, Elif, Paschal, Bryce M., Adli, Mazhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223090/
https://www.ncbi.nlm.nih.gov/pubmed/30404658
http://dx.doi.org/10.1186/s13059-018-1572-4

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