A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss

Selenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of function leads to human SELENON-related myopathies. SelenoN knockout (KO) mouse limb muscles, however, are protected from the disease, and display no major alterations in muscle histology or contractile properties. Inte...

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Detalles Bibliográficos
Autores principales: Pozzer, Diego, Varone, Ersilia, Chernorudskiy, Alexander, Schiarea, Silvia, Missiroli, Sonia, Giorgi, Carlotta, Pinton, Paolo, Canato, Marta, Germinario, Elena, Nogara, Leonardo, Blaauw, Bert, Zito, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223234/
https://www.ncbi.nlm.nih.gov/pubmed/30391828
http://dx.doi.org/10.1016/j.redox.2018.10.017

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