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Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography

PURPOSE: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged with swept-source optical coherence tomography angiography (SS-OCTA). SUBJECTS AND METHODS: This observational, cross-sectional case series included 35 eyes of healthy individuals and 32 e...

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Autores principales: Sugano, Yukinori, Sekiryu, Tetsuju, Furuta, Minoru, Tomita, Ryutaro, Shintake, Hiroaki, Maehara, Hiroki, Ojima, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223397/
https://www.ncbi.nlm.nih.gov/pubmed/30464388
http://dx.doi.org/10.2147/OPTH.S179634
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author Sugano, Yukinori
Sekiryu, Tetsuju
Furuta, Minoru
Tomita, Ryutaro
Shintake, Hiroaki
Maehara, Hiroki
Ojima, Akira
author_facet Sugano, Yukinori
Sekiryu, Tetsuju
Furuta, Minoru
Tomita, Ryutaro
Shintake, Hiroaki
Maehara, Hiroki
Ojima, Akira
author_sort Sugano, Yukinori
collection PubMed
description PURPOSE: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged with swept-source optical coherence tomography angiography (SS-OCTA). SUBJECTS AND METHODS: This observational, cross-sectional case series included 35 eyes of healthy individuals and 32 eyes of 32 patients. Two images of the fovea were taken using SS-OCTA with 3×3 mm squares. Images of the choriocapillaris within 800×800 pixel squares centered at the fovea were analyzed morphometrically using open-source software “AngioTool” that applies a Gaussian recursive filter and multiscale Hessian enhancement. This program’s vessel thickness and intensity parameters can be changed to aid vessel detection. We measured the pairs of images per eye with different parameter sets and calculated the intraclass correlation (ICC) for the morphometrical results. After determining the parameters that produced high reproducibility, we evaluated regional variations in 800×800 pixel mm squares within the fovea. RESULTS: The ICCs for vessel area, total vessel length, vessel diameter index, and mean lacunarity were over 0.9 using the parameters of “vessel thickness” 3–4 and intensity 15 in the group including all subjects. When measurements were performed using these same parameter values, the vessel density and mean vessel diameter index were 60.5% and 19.1±0.389, respectively. Vessel density, vessel length, vessel diameter index, and mean lacunarity did not change significantly within an 800×800 pixel square centered at the fovea except for the 200×200 pixel square at the foveal center. CONCLUSION: SS-OCTA images of the choriocapillaris can be measured with high reproducibility by morphometrical evaluation using open-source software with multiscale Hessian enhancement. Such automated morphometric analysis can provide an objective evaluation of the choriocapillaris.
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spelling pubmed-62233972018-11-21 Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography Sugano, Yukinori Sekiryu, Tetsuju Furuta, Minoru Tomita, Ryutaro Shintake, Hiroaki Maehara, Hiroki Ojima, Akira Clin Ophthalmol Original Research PURPOSE: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged with swept-source optical coherence tomography angiography (SS-OCTA). SUBJECTS AND METHODS: This observational, cross-sectional case series included 35 eyes of healthy individuals and 32 eyes of 32 patients. Two images of the fovea were taken using SS-OCTA with 3×3 mm squares. Images of the choriocapillaris within 800×800 pixel squares centered at the fovea were analyzed morphometrically using open-source software “AngioTool” that applies a Gaussian recursive filter and multiscale Hessian enhancement. This program’s vessel thickness and intensity parameters can be changed to aid vessel detection. We measured the pairs of images per eye with different parameter sets and calculated the intraclass correlation (ICC) for the morphometrical results. After determining the parameters that produced high reproducibility, we evaluated regional variations in 800×800 pixel mm squares within the fovea. RESULTS: The ICCs for vessel area, total vessel length, vessel diameter index, and mean lacunarity were over 0.9 using the parameters of “vessel thickness” 3–4 and intensity 15 in the group including all subjects. When measurements were performed using these same parameter values, the vessel density and mean vessel diameter index were 60.5% and 19.1±0.389, respectively. Vessel density, vessel length, vessel diameter index, and mean lacunarity did not change significantly within an 800×800 pixel square centered at the fovea except for the 200×200 pixel square at the foveal center. CONCLUSION: SS-OCTA images of the choriocapillaris can be measured with high reproducibility by morphometrical evaluation using open-source software with multiscale Hessian enhancement. Such automated morphometric analysis can provide an objective evaluation of the choriocapillaris. Dove Medical Press 2018-11-05 /pmc/articles/PMC6223397/ /pubmed/30464388 http://dx.doi.org/10.2147/OPTH.S179634 Text en © 2018 Sugano et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sugano, Yukinori
Sekiryu, Tetsuju
Furuta, Minoru
Tomita, Ryutaro
Shintake, Hiroaki
Maehara, Hiroki
Ojima, Akira
Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_full Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_fullStr Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_full_unstemmed Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_short Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_sort morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223397/
https://www.ncbi.nlm.nih.gov/pubmed/30464388
http://dx.doi.org/10.2147/OPTH.S179634
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