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Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association for the Study of Intestinal Diseases
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223457/ https://www.ncbi.nlm.nih.gov/pubmed/30301327 http://dx.doi.org/10.5217/ir.2018.00013 |
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author | Lam, Yuk Fai Seto, Wai Kay Tong, Teresa Cheung, Ka Shing Lo, Oswens Hung, Ivan FN Law, Wai Lun Leung, Wai K |
author_facet | Lam, Yuk Fai Seto, Wai Kay Tong, Teresa Cheung, Ka Shing Lo, Oswens Hung, Ivan FN Law, Wai Lun Leung, Wai K |
author_sort | Lam, Yuk Fai |
collection | PubMed |
description | BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. RESULTS: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. CONCLUSIONS: Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy. |
format | Online Article Text |
id | pubmed-6223457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Association for the Study of Intestinal Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-62234572018-11-14 Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer Lam, Yuk Fai Seto, Wai Kay Tong, Teresa Cheung, Ka Shing Lo, Oswens Hung, Ivan FN Law, Wai Lun Leung, Wai K Intest Res Original Article BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. RESULTS: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. CONCLUSIONS: Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy. Korean Association for the Study of Intestinal Diseases 2018-10 2018-10-10 /pmc/articles/PMC6223457/ /pubmed/30301327 http://dx.doi.org/10.5217/ir.2018.00013 Text en © Copyright 2018. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lam, Yuk Fai Seto, Wai Kay Tong, Teresa Cheung, Ka Shing Lo, Oswens Hung, Ivan FN Law, Wai Lun Leung, Wai K Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
title | Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
title_full | Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
title_fullStr | Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
title_full_unstemmed | Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
title_short | Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
title_sort | rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223457/ https://www.ncbi.nlm.nih.gov/pubmed/30301327 http://dx.doi.org/10.5217/ir.2018.00013 |
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