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Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer

BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2...

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Autores principales: Lam, Yuk Fai, Seto, Wai Kay, Tong, Teresa, Cheung, Ka Shing, Lo, Oswens, Hung, Ivan FN, Law, Wai Lun, Leung, Wai K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223457/
https://www.ncbi.nlm.nih.gov/pubmed/30301327
http://dx.doi.org/10.5217/ir.2018.00013
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author Lam, Yuk Fai
Seto, Wai Kay
Tong, Teresa
Cheung, Ka Shing
Lo, Oswens
Hung, Ivan FN
Law, Wai Lun
Leung, Wai K
author_facet Lam, Yuk Fai
Seto, Wai Kay
Tong, Teresa
Cheung, Ka Shing
Lo, Oswens
Hung, Ivan FN
Law, Wai Lun
Leung, Wai K
author_sort Lam, Yuk Fai
collection PubMed
description BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. RESULTS: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. CONCLUSIONS: Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy.
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spelling pubmed-62234572018-11-14 Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer Lam, Yuk Fai Seto, Wai Kay Tong, Teresa Cheung, Ka Shing Lo, Oswens Hung, Ivan FN Law, Wai Lun Leung, Wai K Intest Res Original Article BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. RESULTS: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. CONCLUSIONS: Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy. Korean Association for the Study of Intestinal Diseases 2018-10 2018-10-10 /pmc/articles/PMC6223457/ /pubmed/30301327 http://dx.doi.org/10.5217/ir.2018.00013 Text en © Copyright 2018. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lam, Yuk Fai
Seto, Wai Kay
Tong, Teresa
Cheung, Ka Shing
Lo, Oswens
Hung, Ivan FN
Law, Wai Lun
Leung, Wai K
Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
title Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
title_full Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
title_fullStr Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
title_full_unstemmed Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
title_short Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
title_sort rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223457/
https://www.ncbi.nlm.nih.gov/pubmed/30301327
http://dx.doi.org/10.5217/ir.2018.00013
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