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Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea

BACKGROUND/AIMS: Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in the management of inflammatory bowel disease (IBD) patients. We evaluated immunogenicity for HBV in IBD patients and the response to the HBV vaccination. METHODS: From May 2014 to Augus...

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Autores principales: Chang, Ji Young, Jung, Sung-Ae, Moon, Chang Mo, Kim, Seong-Eun, Jung, Hye-Kyung, Shim, Ki-Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223458/
https://www.ncbi.nlm.nih.gov/pubmed/30301330
http://dx.doi.org/10.5217/ir.2018.00012
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author Chang, Ji Young
Jung, Sung-Ae
Moon, Chang Mo
Kim, Seong-Eun
Jung, Hye-Kyung
Shim, Ki-Nam
author_facet Chang, Ji Young
Jung, Sung-Ae
Moon, Chang Mo
Kim, Seong-Eun
Jung, Hye-Kyung
Shim, Ki-Nam
author_sort Chang, Ji Young
collection PubMed
description BACKGROUND/AIMS: Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in the management of inflammatory bowel disease (IBD) patients. We evaluated immunogenicity for HBV in IBD patients and the response to the HBV vaccination. METHODS: From May 2014 to August 2016, patients diagnosed with IBD were prospectively included and evaluated for antibody to hepatitis B surface antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen. Among the 73 patients who were confirmed with nonimmunity to HBV, 44 patients who had completed the 3-dose HBV vaccination series received a single booster vaccination, while 29 patients who had not completed the vaccinations series or were unsure of receiving the vaccination received a full vaccination series. RESULTS: An optimal response was obtained in 70.5% of the patients in the booster group, and 89.7% of the patients in the full vaccination group. Age younger than 26 years (odds ratio [OR], 6.01; 95% confidence interval [CI], 1.15–31.32; P=0.033) and a complete previous vaccination series (OR, 0.15; 95% CI, 0.03–0.80; P=0.026) were associated with optimal vaccine response. Previous complete vaccination series (OR, 0.11; 95% CI, 0.02–0.73; P=0.022) was the only predictive factor for lower compliance. CONCLUSIONS: The response to the HBV vaccination was lower in patients older than 26 years and for those patients with a complete vaccination history. Since patients with a complete vaccination history also had poor compliance, serum HBV-titers should be checked more thoroughly, and a full vaccination series should be administered in cases when there is a negative response to the booster vaccination.
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spelling pubmed-62234582018-11-14 Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea Chang, Ji Young Jung, Sung-Ae Moon, Chang Mo Kim, Seong-Eun Jung, Hye-Kyung Shim, Ki-Nam Intest Res Original Article BACKGROUND/AIMS: Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in the management of inflammatory bowel disease (IBD) patients. We evaluated immunogenicity for HBV in IBD patients and the response to the HBV vaccination. METHODS: From May 2014 to August 2016, patients diagnosed with IBD were prospectively included and evaluated for antibody to hepatitis B surface antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen. Among the 73 patients who were confirmed with nonimmunity to HBV, 44 patients who had completed the 3-dose HBV vaccination series received a single booster vaccination, while 29 patients who had not completed the vaccinations series or were unsure of receiving the vaccination received a full vaccination series. RESULTS: An optimal response was obtained in 70.5% of the patients in the booster group, and 89.7% of the patients in the full vaccination group. Age younger than 26 years (odds ratio [OR], 6.01; 95% confidence interval [CI], 1.15–31.32; P=0.033) and a complete previous vaccination series (OR, 0.15; 95% CI, 0.03–0.80; P=0.026) were associated with optimal vaccine response. Previous complete vaccination series (OR, 0.11; 95% CI, 0.02–0.73; P=0.022) was the only predictive factor for lower compliance. CONCLUSIONS: The response to the HBV vaccination was lower in patients older than 26 years and for those patients with a complete vaccination history. Since patients with a complete vaccination history also had poor compliance, serum HBV-titers should be checked more thoroughly, and a full vaccination series should be administered in cases when there is a negative response to the booster vaccination. Korean Association for the Study of Intestinal Diseases 2018-10 2018-10-10 /pmc/articles/PMC6223458/ /pubmed/30301330 http://dx.doi.org/10.5217/ir.2018.00012 Text en © Copyright 2018. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chang, Ji Young
Jung, Sung-Ae
Moon, Chang Mo
Kim, Seong-Eun
Jung, Hye-Kyung
Shim, Ki-Nam
Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
title Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
title_full Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
title_fullStr Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
title_full_unstemmed Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
title_short Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea
title_sort response to hepatitis b vaccination in patients with inflammatory bowel disease: a prospective observational study in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223458/
https://www.ncbi.nlm.nih.gov/pubmed/30301330
http://dx.doi.org/10.5217/ir.2018.00012
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