Cargando…

Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women

PURPOSE: There is a dearth of data on clearance of cervical human papillomavirus (HPV) infection among women in West Africa. We examined the clearance of low-risk (lr) and high-risk (hr) cervical HPV infections, and the factors associated with these measures in HIV-negative and HIV-positive women. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Adebamowo, Sally N., Famooto, Ayotunde, Dareng, Eileen O., Olawande, Oluwatoyosi, Olaniyan, Olayinka, Offiong, Richard, Adebamowo, Clement A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223532/
https://www.ncbi.nlm.nih.gov/pubmed/30125130
http://dx.doi.org/10.1200/JGO.17.00129
_version_ 1783369425741676544
author Adebamowo, Sally N.
Famooto, Ayotunde
Dareng, Eileen O.
Olawande, Oluwatoyosi
Olaniyan, Olayinka
Offiong, Richard
Adebamowo, Clement A.
author_facet Adebamowo, Sally N.
Famooto, Ayotunde
Dareng, Eileen O.
Olawande, Oluwatoyosi
Olaniyan, Olayinka
Offiong, Richard
Adebamowo, Clement A.
author_sort Adebamowo, Sally N.
collection PubMed
description PURPOSE: There is a dearth of data on clearance of cervical human papillomavirus (HPV) infection among women in West Africa. We examined the clearance of low-risk (lr) and high-risk (hr) cervical HPV infections, and the factors associated with these measures in HIV-negative and HIV-positive women. METHODS: We studied 630 Nigerian women involved in a study of HPV infection using short polymerase chain reaction fragment-10 assay and line probe assay-25. Research nurses used a cervical brush to collect samples of exfoliated cervical cells from all the study participants. Cox proportional hazards models were used to estimate associations between HIV and HPV infections. RESULTS: The mean age of the study participants was 38 (standard deviation, ± 8) years; 51% were HIV positive. The rate of clearing any HPV infection was 2.0% per month among all women in the study population, 2.5% per month among HIV-negative women, and 1.6% per month, among HIV-positive women. The clearance rate per 1,000 person-months of observation for any lrHPV infection and any hrHPV infection were 9.21 and 8.83, respectively, for HIV-negative women, and 9.38 and 9.37, respectively, for HIV-positive women. In multivariate models, the hazard ratios for HIV-positive compared with HIV-negative women were 0.85 (95% CI, 0.51 to 1.43; P = .55) and 0.95 (95% CI, 0.54 to 1.65; P = .85) for cleared infections with any lrHPV and any hrHPV, respectively. The hazard ratio for HIV-positive compared with HIV-negative women was 0.39 (95% CI, 0.17 to 0.88; P = .02) for cleared infections with any multiple HPV and 0.13 (95% CI, 0.03 to 0.58; P = .007) for cleared infections with multiple hrHPV. CONCLUSION: In this study population, we observed that HIV-positive women were less likely to clear infections with multiple hrHPV types.
format Online
Article
Text
id pubmed-6223532
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Society of Clinical Oncology
record_format MEDLINE/PubMed
spelling pubmed-62235322018-11-13 Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women Adebamowo, Sally N. Famooto, Ayotunde Dareng, Eileen O. Olawande, Oluwatoyosi Olaniyan, Olayinka Offiong, Richard Adebamowo, Clement A. J Glob Oncol Original Report PURPOSE: There is a dearth of data on clearance of cervical human papillomavirus (HPV) infection among women in West Africa. We examined the clearance of low-risk (lr) and high-risk (hr) cervical HPV infections, and the factors associated with these measures in HIV-negative and HIV-positive women. METHODS: We studied 630 Nigerian women involved in a study of HPV infection using short polymerase chain reaction fragment-10 assay and line probe assay-25. Research nurses used a cervical brush to collect samples of exfoliated cervical cells from all the study participants. Cox proportional hazards models were used to estimate associations between HIV and HPV infections. RESULTS: The mean age of the study participants was 38 (standard deviation, ± 8) years; 51% were HIV positive. The rate of clearing any HPV infection was 2.0% per month among all women in the study population, 2.5% per month among HIV-negative women, and 1.6% per month, among HIV-positive women. The clearance rate per 1,000 person-months of observation for any lrHPV infection and any hrHPV infection were 9.21 and 8.83, respectively, for HIV-negative women, and 9.38 and 9.37, respectively, for HIV-positive women. In multivariate models, the hazard ratios for HIV-positive compared with HIV-negative women were 0.85 (95% CI, 0.51 to 1.43; P = .55) and 0.95 (95% CI, 0.54 to 1.65; P = .85) for cleared infections with any lrHPV and any hrHPV, respectively. The hazard ratio for HIV-positive compared with HIV-negative women was 0.39 (95% CI, 0.17 to 0.88; P = .02) for cleared infections with any multiple HPV and 0.13 (95% CI, 0.03 to 0.58; P = .007) for cleared infections with multiple hrHPV. CONCLUSION: In this study population, we observed that HIV-positive women were less likely to clear infections with multiple hrHPV types. American Society of Clinical Oncology 2018-08-20 /pmc/articles/PMC6223532/ /pubmed/30125130 http://dx.doi.org/10.1200/JGO.17.00129 Text en © 2018 by American Society of Clinical Oncology https://creativecommons.org/licenses/by/4.0/ Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/
spellingShingle Original Report
Adebamowo, Sally N.
Famooto, Ayotunde
Dareng, Eileen O.
Olawande, Oluwatoyosi
Olaniyan, Olayinka
Offiong, Richard
Adebamowo, Clement A.
Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women
title Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women
title_full Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women
title_fullStr Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women
title_full_unstemmed Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women
title_short Clearance of Type-Specific, Low-Risk, and High-Risk Cervical Human Papillomavirus Infections in HIV-Negative and HIV-Positive Women
title_sort clearance of type-specific, low-risk, and high-risk cervical human papillomavirus infections in hiv-negative and hiv-positive women
topic Original Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223532/
https://www.ncbi.nlm.nih.gov/pubmed/30125130
http://dx.doi.org/10.1200/JGO.17.00129
work_keys_str_mv AT adebamowosallyn clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT famootoayotunde clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT darengeileeno clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT olawandeoluwatoyosi clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT olaniyanolayinka clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT offiongrichard clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT adebamowoclementa clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen
AT clearanceoftypespecificlowriskandhighriskcervicalhumanpapillomavirusinfectionsinhivnegativeandhivpositivewomen