The JAK2V617F Point Mutation Increases the Osteoclast Forming Ability of Monocytes in Patients with Chronic Myeloproliferative Neoplasms and Makes their Osteoclasts more Susceptible to JAK2 Inhibition

JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and f...

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Detalles Bibliográficos
Autores principales: Spanoudakis, Emmanouil, Papoutselis, Menelaos, Bazdiara, Ioanna, Lamprianidi, Eleftheria, Kordella, Xrisa, Tilkeridis, Constantinos, Tsatalas, Costas, Kotsianidis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223546/
https://www.ncbi.nlm.nih.gov/pubmed/30416690
http://dx.doi.org/10.4084/MJHID.2018.058

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